{"preliminary_commentary":{"by_channel":{"x_thread":8,"podcast":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT04736173\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":null,"indication":"front-line PD-L1-high locally advanced or metastatic NSCLC","name":"ARC-10","nct_id":"NCT04736173","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=arc-10-nct04736173. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"ARC-10","arms":[{"description":"Participants will receive carboplatin, pemetrexed, and paclitaxel by intravenous (IV) infusion.","label":"Arm A - Study Part 1 (Platinum-based Chemotherapy)","type":"ACTIVE_COMPARATOR"},{"description":"Participants will receive zimberelimab monotherapy by IV infusion.","label":"Arm B - Study Part 1 (Zimberelimab Monotherapy)","type":"EXPERIMENTAL"},{"description":"Participants will receive zimberelimab in combination with AB154 by IV infusion.","label":"Arm C - Study Part 1 (Domvanalimab + Zimberelimab Combination Therapy)","type":"EXPERIMENTAL"},{"description":"Participants will receive domvanalimab in combination with zimberelimab by IV infusion.","label":"Arm D - Study Part 2 (Domvanalimab + Zimberelimab Combination Therapy)","type":"EXPERIMENTAL"},{"description":"Participants will receive pembrolizumab by IV infusion.","label":"Arm E - Study Part 2 (Pembrolizumab)","type":"ACTIVE_COMPARATOR"}],"collaborators":["Gilead Sciences"],"completion_date":{"date":"2026-09-17","type":"ACTUAL"},"conditions":["Non Small Cell Lung Cancer","Nonsquamous Non Small Cell Lung Cancer","Squamous Non Small Cell Lung Cancer","Lung Cancer"],"enrollment":{"count":169,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Domvanalimab","otherNames":["AB154"],"type":"DRUG"},{"name":"Zimberelimab","otherNames":["AB122"],"type":"DRUG"},{"name":"Carboplatin","otherNames":[],"type":"DRUG"},{"name":"Paclitaxel","otherNames":[],"type":"DRUG"},{"name":"Pemetrexed","otherNames":[],"type":"DRUG"},{"name":"Pembrolizumab","otherNames":[],"type":"DRUG"}],"last_update":"2026-10-19","lead_sponsor":"Arcus Biosciences, Inc.","official_title":"Official Title: A Phase 2 Study to Evaluate Zimberelimab (AB122) Combined With AB154 in Front-Line, PD-L1-High, Locally Advanced or Metastatic Non-Small Cell Lung Cancer","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2026-09-17","type":"ACTUAL"},"primary_outcomes":[{"measure":"Progression-free Survival (PFS)","timeFrame":"From randomization until death from any cause (up to 7 years)"}],"references":[],"start_date":{"date":"2021-02-08","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer","url":"https://clinicaltrials.gov/study/NCT04736173"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/arc-10-nct04736173"}