{"commentary":{"count":41,"free_build_floor":8,"listing_floor":3,"by_channel":{"youtube":18,"podcast":13,"x_thread":10},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT04839445\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"ARTEMIDE","nct_id":"NCT04839445","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=artemide-nct04839445. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 41+ commentary sources"},"registry":{"acronym":"ARTEMIDE","arms":[{"description":"Induction: remifentanil in total intravenous anesthesia (TIVA), Propofol 2 mg/kg/h and Rocuronium 0.6 mg/kg. Transversus abdominis plane (TAP) block: 20 minutes before surgery. Ropivacaine 0.37% 20ml + dexamethasone 2mg per side. Maintenance: TIVA with Propofol, the infusion rate will be adjusted according to the bispectral index system (BIS) values (30 \\<BIS \\<50). Patients will receive additional remifentanil by infusion at 0.02 mcg/kg/min per time if blood pressure and heart rate values exceed 20% pre-operative baseline values. Additional rocuronium 0.1 mg/kg based on clinical needs and train of four (TOF) monitoring. Analgesic starter bolus: 30 minutes before the end of the surgery, paracetamol 1 gr ev and ketorolac 30 mg ev. Postoperative pain: paracetamol 1 gr ev every 8 hours for 36 hours; ketorolac 30 mg ev if NRS \\>4 / morphine 2 mg ev if NRS \\>4 30 min after ketorolac administration. In case of nausea and vomiting ondansetron 4 mg ev.","label":"General anesthesia + TAP block","type":"ACTIVE_COMPARATOR"},{"description":"Erector spinae plane (ESP) block: 20 minutes before surgery. T8 level bilaterally, ropivacaine 0.37% 20ml + dexamethasone 2mg per side.\n\nInduction: Remifentanil in TIVA, Propofol 2 mg/kg/h and Rocuronium 0.6 mg/kg. Maintenance: TIVA with Propofol, the infusion rate will be adjusted according to the BIS values (30 \\<BIS \\<50). Patients will receive additional remifentanil by infusion at 0.02 mcg/kg/min per time if blood pressure and heart rate values exceed 20% pre-operative baseline values. Additional rocuronium 0.1 mg/kg based on clinical needs and TOF monitoring.\n\nAnalgesic starter bolus: 30 minutes before the end of the surgery, paracetamol 1 gr ev and ketorolac 30 mg ev.\n\nPostoperative pain: paracetamol 1 gr ev every 8 hours for 36 hours; ketorolac 30 mg ev if NRS \\>4 / morphine 2 mg ev if NRS \\>4 30 min after ketorolac administration. In case of nausea and vomiting ondansetron 4 mg ev.","label":"General anesthesia + ESP block","type":"ACTIVE_COMPARATOR"}],"collaborators":[],"completion_date":{"date":"2022-08-31","type":"ACTUAL"},"conditions":["Anesthesia","Gynecologic Cancer"],"enrollment":{"count":78,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"General anesthesia + TAP block","type":"PROCEDURE"},{"name":"General anesthesia + ESP block","type":"PROCEDURE"}],"last_update":"2022-10-24","lead_sponsor":"AUSL Romagna Rimini","official_title":"Comparison of Efficacy of Ultrasound-guided Erector Spinae Place Block Versus Transversus Abdominis Plane Block for Intra and Postoperative Pain Control in Total Laparoscopic Hysterectomy: a Randomized Controlled Trial","overall_status":"COMPLETED","phases":["NA"],"primary_completion_date":{"date":"2022-08-31","type":"ACTUAL"},"primary_outcomes":[{"measure":"Postoperative pain control","timeFrame":"12 hours"}],"references":[{"citation":"Jones JH, Aldwinckle R. Interfascial Plane Blocks and Laparoscopic Abdominal Surgery: A Narrative Review. Local Reg Anesth. 2020 Oct 23;13:159-169. doi: 10.2147/LRA.S272694. eCollection 2020.","pmid":"33122942","type":"RESULT"},{"citation":"Bagaphou CT, Santonastaso DP, Rispoli M, Piraccini E, Fusco P, Gori F. Bilateral continuous erector spinae plane block: an alternative to epidural catheter for major open abdominal surgery. Minerva Anestesiol. 2020 Sep;86(9):993-994. doi: 10.23736/S0375-9393.20.14557-7. Epub 2020 Jun 2. No abstract available.","pmid":"32490608","type":"RESULT"}],"start_date":{"date":"2021-02-22","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"ESP vs TAP in Total Laparoscopic Hysterectomy","url":"https://clinicaltrials.gov/study/NCT04839445"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/artemide-nct04839445"}