{"preliminary_commentary":{"by_channel":{"x_thread":10,"podcast":5,"youtube":2},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02016781\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":[],"indication":"intermediate-2 and high-risk myelodysplastic syndrome","name":"BMT CTN 1102","nct_id":"NCT02016781","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=bmt-ctn-1102-nct02016781. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":1250,"size":"standard","size_rule":"Standard: 151–300 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Reduced intensity conditioning allogeneic hematopoietic cell transplantation (RIC-alloHCT)","label":"Transplant","type":"ACTIVE_COMPARATOR"},{"description":"The specific non-transplant treatment regimen will be at the discretion of the treating physician.","label":"Hypomethylating Therapy / Best Supportive Care","type":"ACTIVE_COMPARATOR"}],"collaborators":["National Heart, Lung, and Blood Institute (NHLBI)","National Cancer Institute (NCI)","Blood and Marrow Transplant Clinical Trials Network","National Marrow Donor Program"],"completion_date":{"date":"2021-10-05","type":"ACTUAL"},"conditions":["MDS"],"enrollment":{"count":384,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"Allogeneic Hematopoietic Cell Transplant","otherNames":["RIC alloHCT"],"type":"PROCEDURE"},{"name":"Hypomethylating Therapy / Best Supportive Care","otherNames":["Non-transplant"],"type":"PROCEDURE"}],"last_update":"2023-03-03","lead_sponsor":"Medical College of Wisconsin","official_title":"A Multi-Center Biologic Assignment Trial Comparing Allogeneic Hematopoietic Cell Transplant to Hypomethylating Therapy or Best Supportive Care in Patients w/Intermediate-2 & High Risk Myelodysplastic Syndrome (BMTCTN1102)","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2021-10-05","type":"ACTUAL"},"primary_outcomes":[{"measure":"Percentage of Participants With Overall Survival (OS)","timeFrame":"3 years"}],"references":[{"citation":"Saber W, Le Rademacher J, Sekeres M, Logan B, Lewis M, Mendizabal A, Leifer E, Appelbaum FR, Horowitz MM, Nakamura R, Cutler CS. Multicenter biologic assignment trial comparing reduced-intensity allogeneic hematopoietic cell transplant to hypomethylating therapy or best supportive care in patients aged 50 to 75 with intermediate-2 and high-risk myelodysplastic syndrome: Blood and Marrow Transplant Clinical Trials Network #1102 study rationale, design, and methods. Biol Blood Marrow Transplant. 2014 Oct;20(10):1566-72. doi: 10.1016/j.bbmt.2014.06.010. Epub 2014 Jun 24.","pmid":"24972249","type":"BACKGROUND"},{"citation":"Saber W, Bansal A, Li L, Scott BL, Sangaralingham LR, Thao V, Roth JA, Wright W, Steuten LMG, Pidala JA, Mishra A, Maziarz RT, Westervelt P, McGuirk JP, Cutler C, Nakamura R, Ramsey SD. Cost-Effectiveness of Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Older Patients With High-Risk Myelodysplastic Syndrome: Analysis of BMT CTN 1102. JCO Oncol Pract. 2024 Apr;20(4):572-580. doi: 10.1200/OP.23.00413. Epub 2024 Jan 23.","pmid":"38261970","type":"DERIVED"},{"citation":"Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network. Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study. J Clin Oncol. 2023 Oct 1;41(28):4497-4510. doi: 10.1200/JCO.23.00866. Epub 2023 Aug 22.","pmid":"37607457","type":"DERIVED"},{"citation":"Cusatis R, Martens MJ, Nakamura R, Cutler CS, Saber W, Lee SJ, Logan BR, Shaw BE, Gregory A, D'Souza A, Hamilton BK, Horowitz MM, Flynn KE. Health-related quality of life in reduced-intensity hematopoietic cell transplantation based on donor availability in patients aged 50-75 with advanced myelodysplastic syndrome: BMT CTN 1102. Am J Hematol. 2023 Feb;98(2):229-250. doi: 10.1002/ajh.26768. Epub 2022 Nov 21.","pmid":"36251401","type":"DERIVED"},{"citation":"Nakamura R, Saber W, Martens MJ, Ramirez A, Scott B, Oran B, Leifer E, Tamari R, Mishra A, Maziarz RT, McGuirk J, Westervelt P, Vasu S, Patnaik M, Kamble R, Forman SJ, Sekeres MA, Appelbaum F, Mendizabal A, Logan B, Horowitz M, Cutler C. Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50-75 Years of Age With Advanced Myelodysplastic Syndrome. J Clin Oncol. 2021 Oct 20;39(30):3328-3339. doi: 10.1200/JCO.20.03380. Epub 2021 Jun 9.","pmid":"34106753","type":"DERIVED"}],"start_date":{"date":"2013-12-16","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Allo vs Hypomethylating/Best Supportive Care in MDS (BMTCTN1102)","url":"https://clinicaltrials.gov/study/NCT02016781"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/bmt-ctn-1102-nct02016781"}