{"preliminary_commentary":{"by_channel":{"youtube":13,"podcast":12,"x_thread":4,"x_video":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT03662126\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":null,"indication":"myelofibrosis relapsed or refractory to JAK inhibitor treatment","name":"BOREAS","nct_id":"NCT03662126","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=boreas-nct03662126. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"BOREAS","arms":[{"description":"KRT-232 120 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)","label":"Part A Cohort 1","type":"EXPERIMENTAL"},{"description":"KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-21 (21-day cycles)","label":"Part A Cohort 2","type":"EXPERIMENTAL"},{"description":"KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)","label":"Part A Cohort 3","type":"EXPERIMENTAL"},{"description":"KRT-232 240 mg by mouth once daily for Days 1-5, off treatment for Days 6-28 (28-day cycles)","label":"Part A Cohort 4b","type":"EXPERIMENTAL"},{"description":"KRT-232 240 mg by mouth once daily for Days 1-7, off treatment for Days 8-28 (28-day cycles)","label":"Part B Arm 1 KRT-232","type":"EXPERIMENTAL"},{"description":"Best available therapy at the discretion of the investigator, on a 28-day cycle.","label":"Part B Arm 2 Best Available Therapy","type":"ACTIVE_COMPARATOR"}],"collaborators":[],"completion_date":{"date":"2025-12-31","type":"ESTIMATED"},"conditions":["Primary Myelofibrosis (PMF)","Post-Polycythemia Vera MF (Post-PV-MF)","Post-Essential Thrombocythemia MF (Post-ET-MF)"],"enrollment":{"count":385,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"KRT-232","otherNames":[],"type":"DRUG"},{"name":"Best Available Therapy (BAT)","otherNames":[],"type":"DRUG"}],"last_update":"2023-04-28","lead_sponsor":"Kartos Therapeutics, Inc.","official_title":"A Phase 2/3 Randomized, Controlled, Open-Label Study of KRT 232 in Subjects With Primary Myelofibrosis (PMF), Post Polycythemia Vera MF (Post-PV-MF), Or Post Essential Thrombocythemia MF (Post-ET-MF) Who Are Relapsed or Refractory to Janus Kinase (JAK) Inhibitor Treatment","overall_status":"UNKNOWN","phases":["PHASE2","PHASE3"],"primary_completion_date":{"date":"2023-12-31","type":"ESTIMATED"},"primary_outcomes":[{"measure":"(Part A Only) Spleen Volume Reduction (SVR)","timeFrame":"24 weeks"},{"measure":"(Part B Only) Spleen Volume Reduction (SVR)","timeFrame":"24 Weeks"}],"references":[{"citation":"Al-Ali, H.K.; Delgado, R.G.; Lange, A.; Pluta, A.; McLornan, D.; Vachhani, P.; Damaj, G.L.; Jost, P.J.; Rejto, L.; Hus, M.; et al. KRT-232, A First-In-Class, Murine Double Minute 2 Inhibitor, for Myelofibrosis Relapsed or Refractory to Janus-Associated Kinase Inhibitor Treatment. Eha. Libr. 2020, 295035, S215","pmid":null,"type":"BACKGROUND"}],"start_date":{"date":"2019-01-15","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment","url":"https://clinicaltrials.gov/study/NCT03662126"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/boreas-nct03662126"}