{"preliminary_commentary":{"by_channel":{"x_thread":5,"youtube":4,"podcast":3,"x_video":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT06056791\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":[["INKmune"]],"indication":"metastatic castration-resistant prostate cancer","name":"CaRe","nct_id":"NCT06056791","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=care-nct06056791. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. 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Approximately 12 patients will receive 3 weekly IV doses of INKmune on Day 1, 8, and 15 as per the below:\n\nFollowing mBOIN termination and MTD identification, patients will be enrolled in up to two candidate optimal dose levels (no higher than the MTD) for final optimal dose determination.","label":"Cohort 1: 1 x 10^8 INKmune","type":"EXPERIMENTAL"},{"description":"In Dose Escalation: INKmune therapy will be administered by a slow intravenous injection via conventional blood giving set. Approximately 18 patients will receive 3 weekly IV doses of INKmune on Day 1, 8, and 15 as per the below:\n\n* In Cohort 1, the initial planned dose is 1 x 10\\^8 INKmune;\n* In Cohort 2, the weekly dose will increase to 3 x 10\\^8 INKmune;\n* In Cohort 3, the weekly dose will increase to 5 x 10\\^8 INKmune.\n\nIn Dose Expansion: INKmune therapy will be administered by a slow intravenous injection via conventional blood giving set. Approximately 12 patients will receive 3 weekly IV doses of INKmune on Day 1, 8, and 15 as per the below:\n\nFollowing mBOIN termination and MTD identification, patients will be enrolled in up to two candidate optimal dose levels (no higher than the MTD) for final optimal dose determination.","label":"Cohort 2: 3 x 10^8 INKmune","type":"EXPERIMENTAL"},{"description":"In Dose Escalation: INKmune therapy will be administered by a slow intravenous injection via conventional blood giving set. Approximately 18 patients will receive 3 weekly IV doses of INKmune on Day 1, 8, and 15 as per the below:\n\n* In Cohort 1, the initial planned dose is 1 x 10\\^8 INKmune;\n* In Cohort 2, the weekly dose will increase to 3 x 10\\^8 INKmune;\n* In Cohort 3, the weekly dose will increase to 5 x 10\\^8 INKmune.\n\nIn Dose Expansion: INKmune therapy will be administered by a slow intravenous injection via conventional blood giving set. Approximately 12 patients will receive 3 weekly IV doses of INKmune on Day 1, 8, and 15 as per the below:\n\nFollowing mBOIN termination and MTD identification, patients will be enrolled in up to two candidate optimal dose levels (no higher than the MTD) for final optimal dose determination.","label":"Cohort 3: 5 x 10^8 INKmune","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2025-09-10","type":"ACTUAL"},"conditions":["Cancer","Metastatic Castration-resistant Prostate Cancer","mCRPC"],"enrollment":{"count":12,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"INKmune","otherNames":[],"type":"BIOLOGICAL"}],"last_update":"2026-02-27","lead_sponsor":"Inmune Bio, Inc.","official_title":"An Open-label, Phase I/IIa Dose Escalation and Expansion Study to Determine the Safety and Clinical Activity of an Immune Priming Cell Therapy (INKmune) in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)","overall_status":"COMPLETED","phases":["PHASE1","PHASE2"],"primary_completion_date":{"date":"2025-09-10","type":"ACTUAL"},"primary_outcomes":[{"measure":"Determine the optimal concentration of INKmune therapy to be used in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Determine the optimal concentration of INKmune therapy to be used in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Determine the optimal concentration of INKmune therapy to be used in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Determine the optimal concentration of INKmune therapy to be used in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Evaluate the safety and tolerability of INKmune therapy in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Evaluate the safety and tolerability of INKmune therapy in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Evaluate the safety and tolerability of INKmune therapy in patients with mCRPC.","timeFrame":"2-3 years"},{"measure":"Evaluate the safety and tolerability of INKmune therapy in patients with mCRPC.","timeFrame":"2-3 years"}],"references":[{"citation":"Siegel RL, Miller KD, Jemal A. 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