{"preliminary_commentary":{"by_channel":{"podcast":2,"x_thread":2,"youtube":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"name":"CHRONO","nct_id":"NCT04722341","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=chrono-nct04722341. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"8-hour daily eating period. Participants eating window must start within 2 hours of waking up and no later than 9 am.","label":"Time-Restricted Eating (TRE)","type":"EXPERIMENTAL"},{"description":"More than equal to a 12-hour daily eating period","label":"Control","type":"ACTIVE_COMPARATOR"}],"collaborators":["National Cancer Institute (NCI)","University of Alabama at Birmingham","Harvard University"],"completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"conditions":["Colorectal Cancer","Breast Cancer"],"enrollment":{"count":175,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Time-Restricted Eating (TRE)","otherNames":[],"type":"BEHAVIORAL"},{"name":"Control","otherNames":[],"type":"BEHAVIORAL"}],"last_update":"2025-12-16","lead_sponsor":"Cedars-Sinai Medical Center","official_title":"Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators","overall_status":"RECRUITING","phases":["NA"],"primary_completion_date":{"date":"2026-06-30","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Pathologic Complete Response (pCR) and Organ Preservation Rate","timeFrame":"at end of 6-month intervention"},{"measure":"Patient-Reported AEs (PRO-CTCAEs)","timeFrame":"at end of 6-month intervention"}],"references":[{"citation":"Salvy SJ, Figueiredo JC, Atkins KM, Hollis RH, Jahan N, Gunnells DJ, Sleight AG, Gresham G, Diniz MA, Richman JS, Gong J, Zaghiyan K, Heslin MJ, Lee KJ, Sarfraz H, Peterson CM. The CHRONO trial: Protocol for a randomized controlled trial of early time-restricted eating in patients with breast or rectal cancer. Nutr Res. 2026 Jul;151:77-94. doi: 10.1016/j.nutres.2026.04.016. Epub 2026 May 2.","pmid":"42190452","type":"DERIVED"}],"start_date":{"date":"2022-01-01","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators","url":"https://clinicaltrials.gov/study/NCT04722341"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/chrono-nct04722341"}