{"preliminary_commentary":{"by_channel":{"youtube":2,"podcast":2,"x_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":[["sonesitatug vedotin (AZD0901)"]],"indication":"claudin 18.2-expressing advanced solid tumors","name":"CLARITY-PanTumour01","nct_id":"NCT06219941","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=clarity-pantumour01-nct06219941. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Sub Study 1 will investigate AZD0901 monotherapy in order to evaluate the safety, tolerability, and efficacy of AZD0901.","label":"Sub Study 1 - AZD0901 MONOTHERAPY","type":"EXPERIMENTAL"},{"description":"Substudy 2 will investigate the safety and efficacy of AZD0901 as first line systemic treatment used in combination with different chemotherapy agents","label":"Sub Study 2 - AZD0901 IN COMBINATION WITH ANTI-CANCER AGENTS IN PANCREATIC DUCTAL ADENOCARCINOMA","type":"EXPERIMENTAL"},{"description":"Substudy 3 Further evaluate the preliminary anti-tumour activity of AZD0901 monotherapy by assessment of DRR.","label":"Sub Study 3: AZD0901 MONOTHERAPY IN BILIARY TRACT CANCER","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2027-06-28","type":"ESTIMATED"},"conditions":["Gastric Cancer","Gastroesophageal Junction Cancer","Biliary Tract Cancer","Pancreatic Ductal Adenocarcinoma"],"enrollment":{"count":226,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"AZD0901","otherNames":["CMG901"],"type":"DRUG"},{"name":"5-Fluorouracil","otherNames":["5-FU"],"type":"DRUG"},{"name":"Leucovorin","otherNames":["LV"],"type":"DRUG"},{"name":"l-leucovorin","otherNames":["I-LV"],"type":"DRUG"},{"name":"Irinotecan","otherNames":["Camptosar"],"type":"DRUG"},{"name":"Nanoliposomal Irinotecan","otherNames":["ONIVYDE"],"type":"DRUG"},{"name":"Gemcitabine","otherNames":["Gemzar"],"type":"DRUG"}],"last_update":"2026-09-30","lead_sponsor":"AstraZeneca","official_title":"A Phase II, Open-label, Multi-centre Study to Evaluate Safety, Tolerability, Efficacy, PK, and Immunogenicity of AZD0901 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Tumours Expressing Claudin 18.2 (CLARITY-PanTumour01)","overall_status":"RECRUITING","phases":["PHASE2"],"primary_completion_date":{"date":"2026-11-17","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Incidence of adverse events (AEs), serious AEs (SAEs). Changes from baseline in clinical laboratory parameters, vital signs, ECGs and physical examination. Rate of AEs leading to discontinuation of AZD0901, Occurrence of DLTs.","timeFrame":"30 days post treatment completion. AE Follow Up for 90 days post AZD0901 discontinuation."},{"measure":"Objective Response Rate (ORR).","timeFrame":"From date of first dose of AZD0901 up until progression, or the last evaluable assessment in the absence of progression (approximately 2 years)."}],"references":[],"start_date":{"date":"2023-12-13","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2","url":"https://clinicaltrials.gov/study/NCT06219941"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/clarity-pantumour01-nct06219941"}