{"preliminary_commentary":{"by_channel":{"x_thread":3},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":null,"indication":null,"name":"COAST","nct_id":"NCT03822351","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=coast-nct03822351. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"COAST","arms":[{"description":"durvalumab IV","label":"Control Arm (Durvalumab monotherapy)","type":"EXPERIMENTAL"},{"description":"durvalumab IV and oleclumab IV","label":"Arm A (durvalumab + oleclumab):","type":"EXPERIMENTAL"},{"description":"durvalumab IV and monalizumab IV","label":"Arm B (durvalumab + monalizumab)","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2023-07-18","type":"ACTUAL"},"conditions":["Stage III Non-small Cell Lung Cancer","Unresectable"],"enrollment":{"count":189,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"Durvalumab + Oleclumab","otherNames":["Durvalumab (MEDI-4736)","Oleclumab (MEDI-9447)"],"type":"DRUG"},{"name":"Durvalumab","otherNames":["Durvalumab (MEDI-4736)"],"type":"DRUG"},{"name":"Durvalumab + Monalizumab","otherNames":["Durvalumab (MEDI-4736)","Monalizumab (IPH2201)"],"type":"DRUG"}],"last_update":"2024-10-08","lead_sponsor":"MedImmune LLC","official_title":"A Phase 2 Open-label, Multicenter, Randomized, Multidrug Platform Study of Durvalumab (MEDI4736) Alone or in Combination With Novel Agents in Subjects With Locally Advanced, Unresectable (Stage III) Non-small Cell Lung Cancer (COAST)","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2023-07-18","type":"ACTUAL"},"primary_outcomes":[{"measure":"Objective Response (OR) Rate as a Measure of Antitumor Activity of Durvalumab Alone vs Durvalumab in Combination With Novel Agents","timeFrame":"ORR at 16 weeks after randomization is the timing for radiologic assessment of the primary endpoint"}],"references":[{"citation":"Aggarwal C, Martinez-Marti A, Majem M, Barlesi F, Carcereny E, Chu Q, Monnet I, Sanchez-Hernandez A, Dakhil S, Camidge DR, Pillet M, Brown M, Paliompeis C, Dowson A, Cooper ZA, Kumar R, Herbst RS. Durvalumab Alone or Combined With Novel Agents for Unresectable Stage III Non-Small Cell Lung Cancer: Update From the COAST Randomized Clinical Trial. JAMA Netw Open. 2025 Jul 1;8(7):e2518440. doi: 10.1001/jamanetworkopen.2025.18440.","pmid":"40663352","type":"DERIVED"},{"citation":"Herbst RS, Majem M, Barlesi F, Carcereny E, Chu Q, Monnet I, Sanchez-Hernandez A, Dakhil S, Camidge DR, Winzer L, Soo-Hoo Y, Cooper ZA, Kumar R, Bothos J, Aggarwal C, Martinez-Marti A. COAST: An Open-Label, Phase II, Multidrug Platform Study of Durvalumab Alone or in Combination With Oleclumab or Monalizumab in Patients With Unresectable, Stage III Non-Small-Cell Lung Cancer. J Clin Oncol. 2022 Oct 10;40(29):3383-3393. doi: 10.1200/JCO.22.00227. Epub 2022 Apr 22.","pmid":"35452273","type":"DERIVED"}],"start_date":{"date":"2018-12-19","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC","url":"https://clinicaltrials.gov/study/NCT03822351"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/coast-nct03822351"}