{"preliminary_commentary":{"by_channel":{"x_thread":12,"youtube":2},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02931890\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":[["docetaxel","oxaliplatin","capecitabine"],["paclitaxel","carboplatin"]],"indication":"resectable gastric cancer","name":"CRITICS-II","nct_id":"NCT02931890","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=critics-ii-nct02931890. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1250,"size":"standard","size_rule":"Standard: 151–300 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"CRITICS-II","arms":[{"description":"4 courses of 3 weekly DOC followed by surgery","label":"neo-adjuvant chemotherapy followed by surgery","type":"ACTIVE_COMPARATOR"},{"description":"2 courses of 3 weekly DOC and subsequent CRT followed by surgery","label":"neo-adjuvant chemo and subsequent CRT followed by surgery","type":"ACTIVE_COMPARATOR"},{"description":"chemoradiotherapy followed by surgery","label":"neo-adjuvant chemoradiotherapy followed by surgery","type":"ACTIVE_COMPARATOR"}],"collaborators":[],"completion_date":{"date":"2029-03","type":"ESTIMATED"},"conditions":["Gastric Cancer"],"enrollment":{"count":207,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Docetaxel","otherNames":["Taxotere"],"type":"DRUG"},{"name":"Oxaliplatin","otherNames":["Eloxatin"],"type":"DRUG"},{"name":"Capecitabine","otherNames":["Xeloda"],"type":"DRUG"},{"name":"gastrectomy","otherNames":[],"type":"PROCEDURE"},{"name":"radiotherapy of gastric cancer","otherNames":[],"type":"RADIATION"},{"name":"Paclitaxel","otherNames":[],"type":"DRUG"},{"name":"Carboplatin","otherNames":[],"type":"DRUG"}],"last_update":"2024-05-02","lead_sponsor":"The Netherlands Cancer Institute","official_title":"A Multicentre Randomised Phase II Trial of Neo-adjuvant Chemotherapy Followed by Surgery vs. Neo-adjuvant Chemotherapy and Subsequent Chemoradiotherapy Followed by Surgery vs. Neo-adjuvant Chemoradiotherapy Followed by Surgery in Resectable Gastric Cancer","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2"],"primary_completion_date":{"date":"2025-04","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Event-Free survival","timeFrame":"1 year"}],"references":[{"citation":"Klute KA, Shah MA. Evolving Therapeutics for Resectable Esophageal Adenocarcinoma. J Natl Compr Canc Netw. 2025 May;23(5):e257044. doi: 10.6004/jnccn.2025.7044.","pmid":"40340830","type":"DERIVED"},{"citation":"Slagter AE, Jansen EPM, van Laarhoven HWM, van Sandick JW, van Grieken NCT, Sikorska K, Cats A, Muller-Timmermans P, Hulshof MCCM, Boot H, Los M, Beerepoot LV, Peters FPJ, Hospers GAP, van Etten B, Hartgrink HH, van Berge Henegouwen MI, Nieuwenhuijzen GAP, van Hillegersberg R, van der Peet DL, Grabsch HI, Verheij M. CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer. BMC Cancer. 2018 Sep 10;18(1):877. doi: 10.1186/s12885-018-4770-2.","pmid":"30200910","type":"DERIVED"}],"start_date":{"date":"2017-12-21","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Multicentric Randomised Trial for Resectable Gastric Cancer","url":"https://clinicaltrials.gov/study/NCT02931890"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/critics-ii-nct02931890"}