# DESTINY-Gastric01 (NCT03329690)

> DS-8201a in Human Epidermal Growth Factor Receptor 2 (HER2)-Expressing Gastric Cancer [DESTINY-Gastric01]

No report yet. It can be ordered.

- Drugs tested: trastuzumab deruxtecan
- Indication: HER2-expressing advanced gastric or gastroesophageal junction adenocarcinoma

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT03329690
- Phase: PHASE2
- Status: COMPLETED
- Sponsor: Daiichi Sankyo Co., Ltd.
- Conditions: Neoplasm, Gastrointestinal
- Interventions: DS-8201a; Physician's Choice
- Enrollment: 233
- Primary outcome: Percentage of Participants With Objective Response Rate Based on Independent Central Review Following Treatment With DS-8201a in Participants With HER2-Expressing Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (Intent-to-Treat Analysis Set)
- Primary outcome: Percentage of Participants With Best Overall Response Based on Independent Central Review Following Treatment With DS-8201a in Participants With HER2-Expressing Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (Intent-to-Treat Analysis Set)

## Some of the questions raised in the 40 most recent indexed sources

_Automated from the 40 newest of 142 indexed sources (Oct 2021 – Nov 2026). Each question is raised in at least two. Not an Erudio report: no source links. Not medical advice._

- Whether HER2 status must be re-biopsied after trastuzumab progression before starting T-DXd
- Whether T-DXd has meaningful activity in HER2-low IHC 2+/ISH− or IHC 1+ gastric cancer
- Whether findings from an East Asian third-line population apply to Western patients
- Whether baseline HER2 level and MET, EGFR or FGFR2 alterations predict response to T-DXd

## Indexed commentary on DESTINY-Gastric01 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- 62 YouTube videos
- 43 posts on X
- 37 podcast episodes

## Order

Deep, $1,950 at most (a smaller delivered size costs its own price): https://www.erudio.com/contact?report=destiny-gastric01-nct03329690

## Free preview

POST https://www.erudio.com/api/trial-requests with {"nct_id": "NCT03329690", "email": "<work email>"}; the inbox owner confirms by the emailed link.