{"commentary":{"count":373,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":243,"youtube":69,"podcast":58,"x_video":3},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02509286\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"ESOPEC","nct_id":"NCT02509286","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=esopec-nct02509286. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 41+ commentary sources"},"registry":{"acronym":"ESOPEC","arms":[{"description":"The FLOT Arm consists of the FLOT protocol, which consists of 5-Fluorouracil, Leucovorin, Oxaliplatin and Docetaxel. Repetition every 2 weeks (d15, q2w). Four neoadjuvant cycles (8 weeks) prior to surgery and four adjuvant cycles (8 weeks) postoperatively are given.\n\nSurgery is carried out by transthoracic subtotal esophagectomy or by transabdominal distal esophageal resection plus gastrectomy depending on tumor localization.","label":"Perioperative Chemotherapy (FLOT):","type":"EXPERIMENTAL"},{"description":"The CROSS Arm consists of the CROSS protocol, which consists of neoadjuvant radiation therapy (41.4Gy / 23fractions) and concurrent chemotherapy with Carboplatin and Paclitaxel (5 weeks) prior to surgery.\n\nSurgery is carried out by transthoracic subtotal esophagectomy or by transabdominal distal esophageal resection plus gastrectomy depending on tumor localization.","label":"Neoadjuvant Chemoradiation (CROSS):","type":"ACTIVE_COMPARATOR"}],"collaborators":["Clinical Trials Unit Freiburg","University of Freiburg","University of Leipzig","University of Luebeck","University of Hamburg-Eppendorf"],"completion_date":{"date":"2024-12-31","type":"ESTIMATED"},"conditions":["Esophageal Adenocarcinoma (UICC TNM7)","Adenocarcinoma of the Esophagogastric Junction"],"enrollment":{"count":438,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"5-Fluorouracil","type":"DRUG"},{"name":"Leucovorin","type":"DRUG"},{"name":"Oxaliplatin","type":"DRUG"},{"name":"Docetaxel","type":"DRUG"},{"name":"Carboplatin","type":"DRUG"},{"name":"Paclitaxel","type":"DRUG"},{"name":"Neoadjuvant radiation","type":"RADIATION"}],"last_update":"2024-05-08","lead_sponsor":"University Hospital Schleswig-Holstein","official_title":"Perioperative Chemotherapy (FLOT Protocol) Compared To Neoadjuvant Chemoradiation (CROSS Protocol) in Patients With Adenocarcinoma of the Esophagus","overall_status":"UNKNOWN","phases":["PHASE3"],"primary_completion_date":{"date":"2024-05-01","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Overall survival","timeFrame":"At end of trial- up to 3 years in follow up"}],"references":[{"citation":"Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, Rothling N, Schmoor C, Lorenz D, Ell C, Hopt UT, Siewert JR. ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). BMC Cancer. 2016 Jul 19;16:503. doi: 10.1186/s12885-016-2564-y.","pmid":"27435280","type":"BACKGROUND"},{"citation":"Hoeppner J, Brunner T, Schmoor C, Bronsert P, Kulemann B, Claus R, Utzolino S, Izbicki JR, Gockel I, Gerdes B, Ghadimi M, Reichert B, Lock JF, Bruns C, Reitsamer E, Schmeding M, Benedix F, Keck T, Folprecht G, Thuss-Patience P, Neumann UP, Pascher A, Imhof D, Daum S, Strieder T, Krautz C, Zimmermann S, Werner J, Mahlberg R, Illerhaus G, Grimminger P, Lordick F. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer. N Engl J Med. 2025 Jan 23;392(4):323-335. doi: 10.1056/NEJMoa2409408.","pmid":"39842010","type":"DERIVED"}],"start_date":{"date":"2016-01"},"study_type":"INTERVENTIONAL","title":"Perioperative Chemotherapy Compared To Neoadjuvant Chemoradiation in Patients With Adenocarcinoma of the Esophagus","url":"https://clinicaltrials.gov/study/NCT02509286"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/esopec-nct02509286"}