{"commentary":{"count":3,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":3},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":false},"name":"EUROPA","nct_id":"NCT04134598","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=europa-nct04134598. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–12 commentary sources"},"registry":{"acronym":"EUROPA","arms":[{"description":"Breast Irradiation (RT)","label":"Breast Irradiation (RT)","type":"EXPERIMENTAL"},{"description":"Endocrine Therapy (ET)","label":"Endocrine Therapy (ET)","type":"ACTIVE_COMPARATOR"}],"collaborators":["University of Florence"],"completion_date":{"date":"2030-03-31","type":"ESTIMATED"},"conditions":["Breast Cancer"],"enrollment":{"count":926,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Breast irradiation (RT)","type":"RADIATION"},{"name":"Endocrine Therapy (ET): letrozole, anastrozole, exemestane, tamoxifen","type":"DRUG"}],"last_update":"2025-08-29","lead_sponsor":"Azienda Ospedaliero-Universitaria Careggi","official_title":"ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years With Luminal A-like Early Stage Breast Cancer (EUROPA): a Randomized Phase 3 Trial","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE3"],"primary_completion_date":{"date":"2030-03-31","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Patient reported outcome measures (PROM) HRQoL as assessed by European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) C30","timeFrame":"Change from baseline at 24 months"},{"measure":"Time to ipsilateral breast tumor recurrence (IBTR)","timeFrame":"60 months"}],"references":[{"citation":"Meattini I, Poortmans PMP, Marrazzo L, Desideri I, Brain E, Hamaker M, Lambertini M, Miccinesi G, Russell N, Saieva C, Strnad V, Visani L, Kaidar-Person O, Livi L. Exclusive endocrine therapy or partial breast irradiation for women aged >/=70 years with luminal A-like early stage breast cancer (NCT04134598 - EUROPA): Proof of concept of a randomized controlled trial comparing health related quality of life by patient reported outcome measures. J Geriatr Oncol. 2021 Mar;12(2):182-189. doi: 10.1016/j.jgo.2020.07.013. Epub 2020 Jul 29.","pmid":"32739355","type":"RESULT"},{"citation":"Meattini I, De Santis MC, Visani L, Scorsetti M, Fozza A, Meduri B, De Rose F, Bonzano E, Prisco A, Masiello V, La Rocca E, Spoto R, Becherini C, Blandino G, Moscetti L, Colciago RR, Audisio RA, Brain E, Caini S, Hamaker M, Kaidar-Person O, Lambertini M, Marrazzo L, Saieva C, Spanic T, Strnad V, Wheelwright S, Poortmans PMP, Livi L; EUROPA Trial Investigators. Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial. Lancet Oncol. 2025 Jan;26(1):37-50. doi: 10.1016/S1470-2045(24)00661-2. Epub 2024 Dec 12.","pmid":"39675376","type":"RESULT"},{"citation":"Ho AY, Bellon JR. Overcoming Resistance - Omission of Radiotherapy for Low-Risk Breast Cancer. N Engl J Med. 2023 Feb 16;388(7):652-653. doi: 10.1056/NEJMe2216133. No abstract available.","pmid":"36791166","type":"DERIVED"}],"start_date":{"date":"2021-02-08","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"ExclUsive endocRine Therapy Or Radiation theraPy for Women Aged ≥70 Years Early Stage Breast Cancer","url":"https://clinicaltrials.gov/study/NCT04134598"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/europa-nct04134598"}