{"preliminary_commentary":{"by_channel":{"x_thread":16,"youtube":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT04592887\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":[],"indication":"symptomatic bone metastases","name":"FAST-01","nct_id":"NCT04592887","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=fast-01-nct04592887. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":1250,"size":"standard","size_rule":"Standard: 151–300 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"FAST-01","arms":[{"description":null,"label":"FLASH radiotherapy for painful bone metastasis(-es)","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2023-03-27","type":"ACTUAL"},"conditions":["Bone Metastasis"],"enrollment":{"count":10,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"FLASH Radiotherapy","otherNames":[],"type":"RADIATION"}],"last_update":"2024-07-31","lead_sponsor":"Varian, a Siemens Healthineers Company","official_title":"Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases","overall_status":"COMPLETED","phases":["NA"],"primary_completion_date":{"date":"2023-03-27","type":"ACTUAL"},"primary_outcomes":[{"measure":"Workflow Feasibility","timeFrame":"Will be assessed on day of treatment delivery which occurs within 3 weeks of subject enrollment."},{"measure":"Workflow Feasibility","timeFrame":"Will be assessed within 4 weeks of subject enrollment."},{"measure":"Assessment of Radiation-related Toxicities That Are Possibly, Probably, or Definitely Related to FLASH Radiotherapy.","timeFrame":"Assessed from start of treatment until subject death or lost to follow-up, up to 17.8 months"}],"references":[{"citation":"Mascia AE, Daugherty EC, Zhang Y, Lee E, Xiao Z, Sertorio M, Woo J, Backus LR, McDonald JM, McCann C, Russell K, Levine L, Sharma RA, Khuntia D, Bradley JD, Simone CB 2nd, Perentesis JP, Breneman JC. Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. JAMA Oncol. 2023 Jan 1;9(1):62-69. doi: 10.1001/jamaoncol.2022.5843.","pmid":"36273324","type":"DERIVED"},{"citation":"Daugherty EC, Mascia A, Zhang Y, Lee E, Xiao Z, Sertorio M, Woo J, McCann C, Russell K, Levine L, Sharma R, Khuntia D, Bradley J, Simone CB 2nd, Perentesis J, Breneman J. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. JMIR Res Protoc. 2023 Jan 5;12:e41812. doi: 10.2196/41812.","pmid":"36206189","type":"DERIVED"},{"citation":"Maity A, Koumenis C. Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity. Clin Cancer Res. 2022 Sep 1;28(17):3636-3638. doi: 10.1158/1078-0432.CCR-22-1255.","pmid":"35736814","type":"DERIVED"}],"start_date":{"date":"2020-11-03","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Feasibility Study of FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases","url":"https://clinicaltrials.gov/study/NCT04592887"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/fast-01-nct04592887"}