# FORAGER-1 (NCT05614739)

> FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3

No report yet. It can be ordered.

- Drugs tested: vepugratinib (LOXO-435); vepugratinib (LOXO-435) plus pembrolizumab plus enfortumab vedotin; vepugratinib (LOXO-435) plus trastuzumab deruxtecan
- Indication: advanced solid tumors with FGFR3 alterations

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT05614739
- Phase: PHASE1
- Status: RECRUITING
- Sponsor: Eli Lilly and Company
- Conditions: Urinary Bladder Neoplasms; Neoplasm Metastasis; Ureteral Neoplasms
- Interventions: Vepugratinib; Pembrolizumab; enfortumab vedotin; Trastuzumab Deruxtecan; Midazolam; Digoxin; Rosuvastatin
- Enrollment: 677
- Primary outcome: Overall Response Rate (ORR)
- Primary outcome: Pharmacokinetics (PK) of Vepugratinib: Area Under the Concentration versus Time Curve (AUC)
- Primary outcome: PK of Midazolam, Rosuvastatin, and Digoxin Administered Alone and in the Presence of Vepugratinib: Area Under the Concentration versus Time Curve (AUC[0-inf])
- Primary outcome: Complete Response Rate (CRR) in Participants with Low-Grade Intermediate-Risk Non-Muscle Invasive Bladder Cancer (LG IR NMIBC)

## Some of the questions raised in the 24 most recent indexed sources

_Automated from the 24 newest of 27 indexed sources (Feb 2025 – Nov 2026). Each question is raised in at least two. Not an Erudio report: no source links. Not medical advice._

- Whether FGFR3 selectivity avoids erdafitinib's hyperphosphatemia, retinal and nail toxicities
- Whether adding vepugratinib to first-line enfortumab vedotin plus pembrolizumab adds benefit in FGFR3-altered disease
- Whether vepugratinib is active after progression on enfortumab vedotin plus pembrolizumab

## Indexed commentary on FORAGER-1 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- 20 posts on X
- 4 podcast episodes
- 3 YouTube videos

## Order

Deep, $1,950 at most (a smaller delivered size costs its own price): https://www.erudio.com/contact?report=forager-1-nct05614739

## Free preview

POST https://www.erudio.com/api/trial-requests with {"nct_id": "NCT05614739", "email": "<work email>"}; the inbox owner confirms by the emailed link.