{"commentary":{"count":3,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":3},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":false},"name":"HA-PCI","nct_id":"NCT01780675","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=ha-pci-nct01780675. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–12 commentary sources"},"registry":{"acronym":"HA-PCI","arms":[{"description":"Radiation. Prophylactic Cranial Irradiation: 10 times 2.5 Gy (total 25 Gy)","label":"Prophylactic Cranial Irradiation","type":"ACTIVE_COMPARATOR"},{"description":"Radiation. Hippocampal Avoidance PCI. 10 times 2.5 Gy (total 25 Gy).","label":"Hippocampal Avoidance PCI","type":"EXPERIMENTAL"}],"collaborators":["Dutch Cancer Society"],"completion_date":{"date":"2022-01","type":"ACTUAL"},"conditions":["Small Cell Lung Cancer","Lung Cancer"],"enrollment":{"count":168,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Radiation Prophylactic Cranial Irradiation","type":"RADIATION"},{"name":"Radiation Hippocampal Avoidance PCI","type":"RADIATION"}],"last_update":"2022-01-21","lead_sponsor":"The Netherlands Cancer Institute","official_title":"Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance in SCLC a Randomized Phase III Trial","overall_status":"COMPLETED","phases":["PHASE3"],"primary_completion_date":{"date":"2019-04-01","type":"ACTUAL"},"primary_outcomes":[{"measure":"neurocognitive decline","timeFrame":"4 months"}],"references":[{"citation":"Zeng H, Schagen SB, Hendriks LEL, Sanchez-Benavides G, Jaspers JPM, Manero RM, Lievens Y, Murcia-Mejia M, Kuenen M, Rico-Oses M, Albers EAC, Samper P, Houben R, de Ruiter MB, Dieleman EMT, Lopez-Guerra JL, De Jaeger K, Counago F, Lambrecht M, Calvo-Crespo P, Belderbos JSA, De Ruysscher DKM, Rodriguez de Dios N. Impact of HA-PCI on self-reported cognitive functioning and brain metastases in small-cell lung cancer: Pooled findings of NCT01780675 and PREMER trials. Lung Cancer. 2025 Jan;199:108036. doi: 10.1016/j.lungcan.2024.108036. Epub 2024 Nov 23.","pmid":"39615412","type":"DERIVED"},{"citation":"Ishibashi A, Kurosaki H, Miura K, Utsumi N, Sakurai H. Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy. Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045497. doi: 10.1177/15330338211045497.","pmid":"34632876","type":"DERIVED"}],"start_date":{"date":"2013-04"},"study_type":"INTERVENTIONAL","title":"Hippocampus Avoidance PCI vs PCI","url":"https://clinicaltrials.gov/study/NCT01780675"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/ha-pci-nct01780675"}