{"preliminary_commentary":{"by_channel":{"x_thread":7,"podcast":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT04224740\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":null,"indication":"first-line advanced penile cancer","name":"HERCULES","nct_id":"NCT04224740","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=hercules-nct04224740. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"HERCULES","arms":[{"description":"-Pembrolizumab combined with standard of care therapy\n\n* Standard of care therapy: ciplastin 70mg/m² IV D1(or carboplatin AUC 5) plus 5-Fluouracil 1000mg/m²/day IV( continuous infusion on Days 1-4) Q3W for 6 cycles","label":"Pembrolizumab plus standard of care chemotherapy","type":"EXPERIMENTAL"}],"collaborators":["Merck Sharp & Dohme LLC"],"completion_date":{"date":"2023-11-13","type":"ACTUAL"},"conditions":["Penile Carcinoma"],"enrollment":{"count":37,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Pembrolizumab","otherNames":[],"type":"DRUG"},{"name":"Standard of care therapy","otherNames":["Cisplatin(or Carboplatin), 5-fluouracil"],"type":"DRUG"}],"last_update":"2024-03-13","lead_sponsor":"Latin American Cooperative Oncology Group","official_title":"A Phase II Trial of Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2023-11-13","type":"ACTUAL"},"primary_outcomes":[{"measure":"Overall response rate (ORR)","timeFrame":"24 weeks"}],"references":[{"citation":"Cotait Maluf F, Trindade K, Preto D, de Almeida Luz M, Medeiros Milhomem Beato P, Assed Bastos D, Holanda Soares JP, Marcondes Lopes V, Werneck de Carvalho LE, Queiroz Borges Muniz D, Racy DJ, de Jesus RG, Rebelatto TF, Werutsky G, Halabi S, Sabino Marques Monteiro F, Poisl Fay A. Pembrolizumab Plus Platinum-Based Chemotherapy for Patients With Advanced Penile Cancer: The Nonrandomized HERCULES (LACOG 0218) Clinical Trial. JAMA Oncol. 2025 Nov 1;11(11):1314-1320. doi: 10.1001/jamaoncol.2025.3266.","pmid":"40965911","type":"DERIVED"}],"start_date":{"date":"2020-06-15","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer","url":"https://clinicaltrials.gov/study/NCT04224740"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/hercules-nct04224740"}