{"commentary":{"count":71,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":41,"youtube":17,"podcast":12,"x_video":1},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02466737\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"INSEMA","nct_id":"NCT02466737","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=insema-nct02466737. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 41+ commentary sources"},"registry":{"acronym":"INSEMA","arms":[{"description":null,"label":"no axillary surgery","type":"EXPERIMENTAL"},{"description":"standard arm in first randomization","label":"sentinel lymph node biopsy","type":"ACTIVE_COMPARATOR"},{"description":null,"label":"sentinel lymph node biopsy alone","type":"EXPERIMENTAL"},{"description":"standard arm in second randomization","label":"completion axillary lymph node dissection","type":"ACTIVE_COMPARATOR"}],"collaborators":["German Cancer Aid","GBG Forschungs GmbH"],"completion_date":{"date":"2029-12","type":"ESTIMATED"},"conditions":["Breast Cancer"],"enrollment":{"count":5505,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"no axillary surgery versus SLNB","type":"PROCEDURE"},{"name":"SLNB versus completion ALND","type":"PROCEDURE"}],"last_update":"2026-05-01","lead_sponsor":"University of Rostock","official_title":"Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery in Patients With Early-stage Invasive Breast Cancer and Breast-conserving Surgery: a Randomized Prospective Surgical Trial. 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Central Review of Radiation Therapy Planning Among Patients with Breast-Conserving Surgery: Results from a Quality Assurance Process Integrated into the INSEMA Trial. Int J Radiat Oncol Biol Phys. 2020 Jul 15;107(4):683-693. doi: 10.1016/j.ijrobp.2020.04.042. Epub 2020 May 11.","pmid":"32437921","type":"RESULT"},{"citation":"Reimer T, Stachs A, Veselinovic K, Polata S, Muller T, Kuhn T, Heil J, Ataseven B, Reitsamer R, Hildebrandt G, Knauer M, Golatta M, Stefek A, Zahm DM, Thill M, Nekljudova V, Krug D, Loibl S, Gerber B; INSEMA investigators. Patient-reported outcomes for the Intergroup Sentinel Mamma study (INSEMA): A randomised trial with persistent impact of axillary surgery on arm and breast symptoms in patients with early breast cancer. 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N Engl J Med. 2025 Mar 13;392(11):1051-1064. doi: 10.1056/NEJMoa2412063. Epub 2024 Dec 12.","pmid":"39665649","type":"RESULT"},{"citation":"Reimer T, Stachs A, Veselinovic K, Kuehn T, Heil J, Polata S, Marme F, Trapp E, Hildebrandt G, Krug D, Ataseven B, Reitsamer R, Ruth S, Denkert C, Bekes I, Stahl N, Thill M, Strittmatter HJ, Mueller T, Golatta M, Zahm DM, Holtschmidt J, Knauer M, Nekljudova V, Loibl S, Gerber B. Axillary surgery in patients with sentinel node macrometastases: secondary results of the randomized INSEMA trial. NPJ Breast Cancer. 2026 Jan 27;12(1):19. doi: 10.1038/s41523-026-00902-7.","pmid":"41593108","type":"DERIVED"}],"start_date":{"date":"2015-09","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery","url":"https://clinicaltrials.gov/study/NCT02466737"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/insema-nct02466737"}