# KontRASt-01 (NCT04699188)

> Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

No report yet. It can be ordered.

- Drugs tested: opnurasib (JDQ443); opnurasib (JDQ443) plus TNO155; opnurasib (JDQ443) plus tislelizumab
- Indication: advanced KRAS G12C-mutated solid tumors

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT04699188
- Phase: PHASE1, PHASE2
- Status: ACTIVE_NOT_RECRUITING
- Sponsor: Novartis Pharmaceuticals
- Conditions: KRAS G12C Mutant Solid Tumors; Carcinoma, Non-Small-Cell Lung; Carcinoma, Colorectal; Cancer of Lung; Cancer of the Lung; Lung Cancer; Neoplasms, Lung; Neoplasms, Pulmonary; Pulmonary Cancer; Pulmonary Neoplasms
- Interventions: JDQ443; TNO155; tislelizumab
- Enrollment: 344
- Primary outcome: Dose Escalation: Incidence and severity of dose limiting toxicities (DLTs) during the first cycle of monotherapy or combination treatment
- Primary outcome: Dose Escalation: Incidence and severity of adverse events (AEs) and serious adverse events (SAEs)
- Primary outcome: Dose Escalation: Frequency of dose interruptions and reductions, by treatment
- Primary outcome: Dose Escalation: Dose intensity by treatment
- Primary outcome: Dose Expansion: Overall response rate (ORR) per RECIST v1.1, by treatment
- Primary outcome: Dose expansion: Overall intracranial response rate (OIRR) per mRANO-BM
- Primary outcome: Dose expansion: Incidence and severity of AEs and SAEs
- Primary outcome: Dose expansion: frequency of dose interruptions and reductions, by treatment
- Primary outcome: Dose expansion: Dose intensity by treatment
- Primary outcome: Dose expansion: ORR per RECIST 1.1 of JDQ443 single agent in patients with non-small cell lung cancer (JDQ443 dose randomization group only)

## Indexed commentary on KontRASt-01 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- 13 posts on X

## Order

Standard, $1,250 at most (a smaller delivered size costs its own price): https://www.erudio.com/contact?report=kontrast-01-nct04699188

## Free preview

POST https://www.erudio.com/api/trial-requests with {"nct_id": "NCT04699188", "email": "<work email>"}; the inbox owner confirms by the emailed link.