{"preliminary_commentary":{"by_channel":{"x_thread":3},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":[],"indication":"HPV+ oropharyngeal squamous cell carcinoma","name":"MR-ADAPTOR","nct_id":"NCT03224000","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=mr-adaptor-nct03224000. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Modified barium swallow (MBS) performed at baseline and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nSwallowing questionnaire completed at baseline, every week while receiving radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nSymptom questionnaire completed at baseline, every week while receiving radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nVideo-strobe procedure performed at baseline, at week 3 during radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nIMRT planned with MRI guidance. Participants receive an individualized prescription of up to 70 Gy in 33 fractions with radiation therapy (RT) given once daily, 5 days a week, over 6 weeks and 3 days.","label":"MRI Guided Intensity Modulated Radiotherapy (IMRT)","type":"EXPERIMENTAL"},{"description":"Modified barium swallow (MBS) performed at baseline and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nSwallowing questionnaire completed at baseline, every week while receiving radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nSymptom questionnaire completed at baseline, every week while receiving radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nVideo-strobe procedure performed at baseline, at week 3 during radiation therapy, and at 6 months, 2 years, and 5 years after finishing radiation therapy.\n\nIMRT planned by standard-of-care. Participants receive an individualized prescription of up to 70 Gy in 33 fractions with radiation therapy (RT) given once daily, 5 days a week, over 6 weeks and 3 days.","label":"Standard-of-Care Intensity Modulated Radiotherapy (IMRT)","type":"ACTIVE_COMPARATOR"}],"collaborators":["National Cancer Institute (NCI)"],"completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"conditions":["Malignant Neoplasms of Lip Oral Cavity and Pharynx","Oropharyngeal Cancer"],"enrollment":{"count":90,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Modified Barium Swallow (MBS)","otherNames":[],"type":"PROCEDURE"},{"name":"Swallowing Questionnaire","otherNames":["The M.D. Anderson Dysphagia Inventory (MDADI)"],"type":"BEHAVIORAL"},{"name":"Symptom Questionnaire","otherNames":["The M.D. Anderson Symptom Inventory for Head and Neck Cancer (MDASI-HN)"],"type":"BEHAVIORAL"},{"name":"Video-Strobe Procedure","otherNames":[],"type":"PROCEDURE"},{"name":"MRI Guided Intensity Modulated Radiotherapy (IMRT) Planning","otherNames":[],"type":"PROCEDURE"},{"name":"Standard-of-Care Intensity Modulated Radiotherapy (IMRT) Planning","otherNames":[],"type":"PROCEDURE"},{"name":"Intensity Modulated Radiotherapy (IMRT)","otherNames":["Radiation therapy","XRT"],"type":"RADIATION"}],"last_update":"2026-06-11","lead_sponsor":"M.D. Anderson Cancer Center","official_title":"Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2"],"primary_completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Locoregional Control","timeFrame":"6 months post radiation therapy"},{"measure":"Composite Dysphagia Outcome Determined by PEG Tube Dependence at Last Follow-Up","timeFrame":"6 months post radiation therapy"},{"measure":"Composite Dysphagia Outcome Determined by Trace or Frank Aspiration Seen on Modified Barium Swallow Study","timeFrame":"6 months post radiation therapy"},{"measure":"Composite Dysphagia Outcome Determined by Diagnosis of Aspiration Pneumonia","timeFrame":"6 months post radiation therapy"},{"measure":"Composite Dysphagia Outcome Determined by Presence of Pharyngoesophageal Structure on Modified Barium Swallow Study","timeFrame":"6 months post radiation therapy"},{"measure":"Composite Dysphagia Outcome Determined by Presence of Pharyngoesophageal Structure on Endoscopy with Subsequent Need for Dilation","timeFrame":"6 months post radiation therapy"}],"references":[{"citation":"Bahig H, Yuan Y, Mohamed ASR, Brock KK, Ng SP, Wang J, Ding Y, Hutcheson K, McCulloch M, Balter PA, Lai SY, Al-Mamgani A, Sonke JJ, van der Heide UA, Nutting C, Li XA, Robbins J, Awan M, Karam I, Newbold K, Harrington K, Oelfke U, Bhide S, Philippens MEP, Terhaard CHJ, McPartlin AJ, Blanchard P, Garden AS, Rosenthal DI, Gunn GB, Phan J, Cazoulat G, Aristophanous M, McSpadden KK, Garcia JA, van den Berg CAT, Raaijmakers CPJ, Kerkmeijer L, Doornaert P, Blinde S, Frank SJ, Fuller CD. Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial. Clin Transl Radiat Oncol. 2018 Aug 24;13:19-23. doi: 10.1016/j.ctro.2018.08.003. eCollection 2018 Nov.","pmid":"30386824","type":"DERIVED"}],"start_date":{"date":"2018-01-17","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer","url":"https://clinicaltrials.gov/study/NCT03224000"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/mr-adaptor-nct03224000"}