{"preliminary_commentary":{"by_channel":{"x_thread":67,"youtube":18,"podcast":11,"bluesky_thread":10},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT00558519\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"name":"NCT00558519","nct_id":"NCT00558519","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct00558519. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Patients are given a series of leukemia treatments that are divided into several sequential courses and different chemotherapy combinations of treatment. Please see the \"Detailed Description\" section for more information.","label":"Treatment (chemotherapy, radiotherapy)","type":"EXPERIMENTAL"}],"collaborators":["National Cancer Institute (NCI)"],"completion_date":{"date":"2024-06-24","type":"ACTUAL"},"conditions":["Leukemia"],"enrollment":{"count":318,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"cyclophosphamide","otherNames":[],"type":"DRUG"},{"name":"cytarabine","otherNames":[],"type":"DRUG"},{"name":"daunorubicin hydrochloride","otherNames":[],"type":"DRUG"},{"name":"dexamethasone","otherNames":[],"type":"DRUG"},{"name":"doxorubicin hydrochloride","otherNames":[],"type":"DRUG"},{"name":"mercaptopurine","otherNames":[],"type":"DRUG"},{"name":"methotrexate","otherNames":[],"type":"DRUG"},{"name":"pegaspargase","otherNames":[],"type":"DRUG"},{"name":"thioguanine","otherNames":[],"type":"DRUG"},{"name":"vincristine sulfate","otherNames":[],"type":"DRUG"},{"name":"radiation therapy","otherNames":[],"type":"RADIATION"}],"last_update":"2026-04-29","lead_sponsor":"Alliance for Clinical Trials in Oncology","official_title":"An Intergroup Phase II Clinical Trial for Adolescents and Young Adults With Untreated Acute Lymphoblastic Leukemia (ALL)","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2016-09","type":"ACTUAL"},"primary_outcomes":[{"measure":"Complete Response Rate","timeFrame":"Up to 8 years post-registration"},{"measure":"Event-free Survival","timeFrame":"Up to 8 years post-registration"},{"measure":"Disease-free Survival","timeFrame":"Up to 8 years post-registration"},{"measure":"Overall Survival","timeFrame":"Up to 8 years post-registration"},{"measure":"Number of Participants Who Experienced at Least One Grade 3 or Higher Adverse Event at Least Possibly Related to Treatment (Toxicity)","timeFrame":"Up to 10 years post-registration"}],"references":[{"citation":"Bleyer A: Older adolescents and young adults with acute lymphoblastic leukemia (ALL) in the United States: from the lowest to highest death rate and number of deaths--more rationale for the CALBG-SWOG-ECOG C10403 trial based on COG AALL0232. [Abstract] J Clin Oncol 26 (Suppl 15): A-18034, 2008.","pmid":null,"type":"BACKGROUND"},{"citation":"Advani AS, Larsen E, Laumann K, Luger SM, Liedtke M, Devidas M, Chen Z, Yin J, Foster MC, Claxton D, Coffan K, Tallman MS, Appelbaum FR, Erba H, Stone RM, Hunger SP, McNeer JL, Loh ML, Raetz E, Winick N, Carroll W, Larson RA, Stock W. Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia. Blood Adv. 2021 Jan 26;5(2):504-512. doi: 10.1182/bloodadvances.2020002439.","pmid":"33496745","type":"DERIVED"},{"citation":"Stock W, Luger SM, Advani AS, Yin J, Harvey RC, Mullighan CG, Willman CL, Fulton N, Laumann KM, Malnassy G, Paietta E, Parker E, Geyer S, Mrozek K, Bloomfield CD, Sanford B, Marcucci G, Liedtke M, Claxton DF, Foster MC, Bogart JA, Grecula JC, Appelbaum FR, Erba H, Litzow MR, Tallman MS, Stone RM, Larson RA. A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403. Blood. 2019 Apr 4;133(14):1548-1559. doi: 10.1182/blood-2018-10-881961. Epub 2019 Jan 18.","pmid":"30658992","type":"DERIVED"}],"start_date":{"date":"2008-03-12","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia","url":"https://clinicaltrials.gov/study/NCT00558519"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct00558519"}