# NCT03556228 (NCT03556228)

> VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

No report yet. It can be ordered.

- Drugs tested: VMD-928; VMD-928 plus pembrolizumab
- Indication: TrkA overexpression driven solid tumors or lymphoma

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT03556228
- Phase: PHASE1, PHASE2
- Status: RECRUITING
- Sponsor: VM Oncology, LLC
- Conditions: Head and Neck Carcinoma; Adenoid Cystic Carcinoma; Lung Cancer; Non-Small Cell Lung Cancer; Pancreatic Cancer; Mesothelioma; Esophageal Cancer; Any Solid Tumors Progressed After a Prior Immunotherapy; Head and Neck Squamous Cell Carcinoma; Head and Neck Squamous Cell Carcinoma HNSCC; Salivary Gland Carcinomas; Head and Neck Cancers - Salivary Gland; Head and Neck Cancers - Nasopharyngeal; Head and Neck Cancers - Throat; Small Cell Lung Cancer ( SCLC ); Lung Cancer (Locally Advanced or Metastatic); Head and Neck Cancers - Tonsils; Head and Neck Cancers Hypopharynx; Head and Neck Cancers Larynx; Head and Neck Cancers Lip; Head and Neck Cancers Nasopharynx; Head and Neck Cancers Oral Cavity; Head and Neck Cancers; Head and Neck Cancers Oropharynx; Head and Neck Cancers Trachea
- Interventions: VMD-928 100 mg Tablet; VMD-928 Tablet and Pembrolizumab (200 mg)
- Enrollment: 242
- Primary outcome: Number and severity of treatment-emergent Adverse Events (Phase 1)
- Primary outcome: To determine the recommended Phase 2 dose for VMD-928 (Phase 1)
- Primary outcome: To determine the RP2D of VMD-928 in combination with pembrolizumab (Phase 1)
- Primary outcome: Antitumor activity of VMD-928 in subjects with TrkA-driven tumors (Phase 2)
- Primary outcome: Antitumor activity of VMD-928 in combination with pembrolizumab in subjects with TrkA-driven tumors (Phase 2)

## Indexed commentary on NCT03556228 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- 3 posts on X

## Order

Focused, $750 at most (a smaller delivered size costs its own price): https://www.erudio.com/contact?report=nct03556228