{"preliminary_commentary":{"by_channel":{"x_thread":2,"bluesky_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":null,"indication":null,"name":"NCT04573140","nct_id":"NCT04573140","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct04573140. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"PNOC020","arms":[{"description":null,"label":"Adult GBM (Stratum 1)","type":"EXPERIMENTAL"},{"description":null,"label":"Pediatric HGG (Stratum 2)","type":"EXPERIMENTAL"}],"collaborators":["Pediatric Neuro-Oncology Consortium","University of California, San Francisco","CureSearch","Team Jack Foundation","Florida Department of Health","Food and Drug Administration (FDA)"],"completion_date":{"date":"2029-07-01","type":"ESTIMATED"},"conditions":["Adult Glioblastoma","High Grade Glioma","WHO Grade III or IV Malignant Glioma"],"enrollment":{"count":28,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Autologous total tumor mRNA and pp65 full length (fl) lysosomal associated membrane protein (LAMP) mRNA loaded DOTAP liposome vaccine administered intravenously (RNA loaded lipid particles, RNA-LPs)","otherNames":[],"type":"BIOLOGICAL"}],"last_update":"2026-10-30","lead_sponsor":"University of Florida","official_title":"A Phase I/II Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM), and Recurrent/Progressive Medulloblastoma (MB)","overall_status":"RECRUITING","phases":["PHASE1"],"primary_completion_date":{"date":"2027-07-01","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Manufacturing feasibility","timeFrame":"from the date of surgery until adminstration of third vaccine, up to 20 weeks"},{"measure":"Safety of RNA-LP vaccine","timeFrame":"First vaccine through 14 days after administration of the 3rd vaccine."},{"measure":"Determination of Maximum Tolerated Dose","timeFrame":"up to 30 months"}],"references":[{"citation":"Carrera-Justiz S, Aghaee M, Qdaisat S, Weidert F, Garcia GA, Fagman L, Zhang D, Stover B, Moor RSF, Xie C, Goldenberg E, von Roemeling C, Doonan B, Chardon-Robles J, Elliott L, Sawyer WG, Deleyrolle LP, Sahay B, Foster TP, Seligson ND, Rahman M, Ghiaseddin A, Castillo P, Lee JH, Silver NL, Doty A, Ligon JA, Milner RJ, Mitchell D, Mendez-Gomez H, Moore H, Sayour EJ. Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors. J Immunother Cancer. 2025 Nov 11;13(11):e011817. doi: 10.1136/jitc-2025-011817.","pmid":"41218853","type":"DERIVED"},{"citation":"Melnick K, Dastmalchi F, Mitchell D, Rahman M, Sayour EJ. Contemporary RNA Therapeutics for Glioblastoma. Neuromolecular Med. 2022 Mar;24(1):8-12. doi: 10.1007/s12017-021-08669-9. Epub 2021 Jun 8.","pmid":"34101090","type":"DERIVED"}],"start_date":{"date":"2021-12-13","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)","url":"https://clinicaltrials.gov/study/NCT04573140"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct04573140"}