{"preliminary_commentary":{"by_channel":{"bluesky_thread":2,"x_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":false},"name":"NCT05707273","nct_id":"NCT05707273","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct05707273. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Patients undergo T cell leukapheresis, receive fludarabine and cyclophosphamide IV, and then receive CD19-CAR T cell infusion IV on study.","label":"Treatment (CD19-CAR T cells)","type":"EXPERIMENTAL"}],"collaborators":["National Cancer Institute (NCI)"],"completion_date":{"date":"2027-09-21","type":"ESTIMATED"},"conditions":["B Acute Lymphoblastic Leukemia"],"enrollment":{"count":18,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Autologous Anti-CD19 CAR-expressing T Lymphocytes","otherNames":["Autologous Anti-CD19-CAR T Cells"],"type":"DRUG"},{"name":"Biospecimen Collection","otherNames":["Biological Sample Collection","Biospecimen Collected","Specimen Collection"],"type":"PROCEDURE"},{"name":"Bone Marrow Aspiration and Biopsy","otherNames":[],"type":"PROCEDURE"},{"name":"Cyclophosphamide","otherNames":["(-)-Cyclophosphamide","2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate","Carloxan","Ciclofosfamida","Ciclofosfamide","Cicloxal","Clafen","Claphene","CP monohydrate","CTX","CYCLO-cell","Cycloblastin","Cycloblastine","Cyclophospham","Cyclophosphamid monohydrate","Cyclophosphamide Monohydrate","Cyclophosphamidum","Cyclophosphan","Cyclophosphane","Cyclophosphanum","Cyclostin","Cyclostine","Cytophosphan","Cytophosphane","Cytoxan","Fosfaseron","Genoxal","Genuxal","Ledoxina","Mitoxan","Neosar","Revimmune","Syklofosfamid","WR- 138719"],"type":"DRUG"},{"name":"Fludarabine","otherNames":["Fluradosa"],"type":"DRUG"},{"name":"Leukapheresis","otherNames":["Leukocytopheresis","Therapeutic Leukopheresis"],"type":"PROCEDURE"},{"name":"Questionnaire Administration","otherNames":[],"type":"OTHER"}],"last_update":"2026-10-08","lead_sponsor":"City of Hope Medical Center","official_title":"A Pilot Study of CD19-Specific Car T Cells as Consolidation for Older Adults With Acute Lymphoblastic Leukemia in First Remission","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE1"],"primary_completion_date":{"date":"2027-09-21","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Incidence of dose-limiting toxicity (DLT)","timeFrame":"Up to 28 days after CD19-chimeric antigen receptor (CAR) T cell infusion"},{"measure":"Incidence of adverse events","timeFrame":"Up to 15 years"}],"references":[{"citation":"Aldoss I, Goldberg L, Zhang J, Artz AS, Clark MC, Guan M, Espinosa R, Abimannan T, Wu J, Garcia B, Haas ER, Pathak KV, Lovell B, Pirrotte P, Agrawal V, Sanani N, Kasten S, Tilakawardane D, Wagner JR, Paul J, Shan H, Khaled S, Budde LE, Koller PB, Stein AS, Pullarkat VA, Salhotra A, Aribi A, Marcucci G, Wang X, Forman SJ. CAR T Cell Therapy as a Definitive Consolidation for Older Adults with B-ALL in First Complete Remission. Blood Adv. 2026 Jun 24:bloodadvances.2026020963. doi: 10.1182/bloodadvances.2026020963. Online ahead of print.","pmid":"42341322","type":"DERIVED"}],"start_date":{"date":"2023-04-26","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"CD19-Car T Cell Therapy for the Treatment of Older Adults With Acute Lymphoblastic Leukemia in First Remission","url":"https://clinicaltrials.gov/study/NCT05707273"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct05707273"}