{"preliminary_commentary":{"by_channel":{"x_thread":99,"youtube":11,"podcast":11,"x_video":4},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT06396065\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"name":"NCT06396065","nct_id":"NCT06396065","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct06396065. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Subjects will receive AK112 Plus Pemetrexed and Carboplatin via intravenous infusion (IV) Q3W, up to 4 cycles. Afterward, AK112 Plus Pemetrexed will be used for maintenance treatment (administered on Day 1 of each cycle, Q3W) up to 2 years.","label":"AK112 in combination with Pemetrexed and Carboplatin","type":"EXPERIMENTAL"},{"description":"Subjects will receive Placebo Plus Pemetrexed and Carboplatin via intravenous infusion (IV) Q3W, up to 4 cycles in treatment periods per the randomization schedule. Afterward, Placebo Plus Pemetrexed will be used for maintenance treatment (administered on Day 1 of each cycle, Q3W) up to 2 years.","label":"Placebo in combination with Pemetrexed and Carboplatin","type":"ACTIVE_COMPARATOR"}],"collaborators":["Akeso"],"completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"conditions":["Non-Squamous Non-small Cell Lung Cancer"],"enrollment":{"count":420,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"AK112 Injection","otherNames":["Pemetrexed","Carboplatin"],"type":"DRUG"},{"name":"Placebo Injection","otherNames":["Pemetrexed","Carboplatin"],"type":"DRUG"}],"last_update":"2026-07-28","lead_sponsor":"Summit Therapeutics","official_title":"A Randomized, Double-blind, Multi-center, Phase III Study of AK112 or Placebo Combined With Pemetrexed and Carboplatin in Patients With EGFR-mutant Locally Advanced or Metastatic Non-squamous NSCLC Who Have Failed to EGFR-TKI Treatment","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE3"],"primary_completion_date":{"date":"2025-04-12","type":"ACTUAL"},"primary_outcomes":[{"measure":"Progression-free survival (PFS)","timeFrame":"Up to 2 years"},{"measure":"Overall Survival (OS) in the ITT population","timeFrame":"Up to 2 years"}],"references":[{"citation":"Le X, Passaro A, Zhao Y, Huang Y, Laskin J, Rodriguez-Abreu D, Calles A, Bazhenova L, Lo Russo G, Leighl NB, Cappuzzo F, Girard N, Popat S, Fang W, Luo Y, Li W, He Z, Zhao H, Li M, Song Q, Zhao H, El Darsa H, Monnet I, Cobo Dols M, Garcia Campelo R, Jotte R, Berz D, Spira A, Perol M, Nagasaka M, West H, Styles L, Li J, Clow F, Goldman J, Zhang L. Ivonescimab plus chemotherapy versus placebo plus chemotherapy in patients with advanced EGFR-mutated non-small-cell lung cancer after disease progression on EGFR tyrosine kinase inhibitor therapy (HARMONi): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2026 Sep;27(9):1094-1109. doi: 10.1016/S1470-2045(26)00282-2.","pmid":"42636833","type":"DERIVED"}],"start_date":{"date":"2023-05-04","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Phase III Study of AK112 for NSCLC Patients","url":"https://clinicaltrials.gov/study/NCT06396065"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct06396065"}