{"preliminary_commentary":{"by_channel":{"x_thread":2,"bluesky_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":false},"name":"NCT06403735","nct_id":"NCT06403735","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct06403735. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"patients with advanced solid tumors harboring a KRAS G12D mutation were administrated with QLC1101 orally in a total of 6 dose groups at 100,200,400,600,900, and 1200 mg BID","label":"QLC1101","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2027-04-30","type":"ESTIMATED"},"conditions":["Non-small Cell Lung Cancer","Colorectal Cancer","Pancreatic Cancer","Solid Tumor"],"enrollment":{"count":250,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"QLC1101","otherNames":[],"type":"DRUG"}],"last_update":"2024-05-08","lead_sponsor":"Qilu Pharmaceutical Co., Ltd.","official_title":"A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of QLC1101 Monotherapy in the Treatment of Patients With Advanced Solid Tumors Harboring a KRAS G12D Mutation","overall_status":"RECRUITING","phases":["PHASE1"],"primary_completion_date":{"date":"2026-05-31","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Dose limiting toxicity (DLT)","timeFrame":"25 days after the first dose"},{"measure":"MTD (or MAD)","timeFrame":"1 year"},{"measure":"RP2D","timeFrame":"1.5 years"}],"references":[],"start_date":{"date":"2024-04-25","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Phase I Clinical Study of QLC1101 in Patients With Advanced Solid Tumors","url":"https://clinicaltrials.gov/study/NCT06403735"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct06403735"}