{"preliminary_commentary":{"by_channel":{"x_thread":3,"youtube":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":false},"name":"NCT06985147","nct_id":"NCT06985147","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nct06985147. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"This is an open-label, multicenter, within-participant dose escalation study examining up to 2 dose levels of DISC-3405.","label":"Within-participant dose escalation","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2029-02","type":"ESTIMATED"},"conditions":["Polycythemia Vera (PV)"],"enrollment":{"count":60,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"DISC-3405","otherNames":[],"type":"DRUG"}],"last_update":"2026-07-31","lead_sponsor":"Disc Medicine, Inc","official_title":"A Phase 2, Open-Label Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of DISC-3405 in Participants With Polycythemia Vera (PV)","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2"],"primary_completion_date":{"date":"2027-02","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Number of participants with treatment-related adverse events as assessed by CTCAE","timeFrame":"Up to 365 days"},{"measure":"Incidence of clinically abnormal vital signs","timeFrame":"Up to 365 days"},{"measure":"Incidence of clinically abnormal physical exam","timeFrame":"Up to 365 days"},{"measure":"Incidence of clinically abnormal electrocardiograms","timeFrame":"Up to 365 days"},{"measure":"Incidence of abnormal laboratory test results","timeFrame":"Up to 365 days"}],"references":[],"start_date":{"date":"2025-08-12","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)","url":"https://clinicaltrials.gov/study/NCT06985147"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nct06985147"}