{"preliminary_commentary":{"by_channel":{"x_thread":2,"bluesky_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":false},"name":"NECTORS","nct_id":"NCT04277858","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nectors-nct04277858. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"NECTORS","arms":[{"description":"Docetaxel and Cisplatin x 3 cycles followed by Transoral robotic surgery and neck dissection.\n\nCarboplatin may be used instead of Cisplatin.","label":"Neoadjuvant chemotherapy and surgery","type":"EXPERIMENTAL"}],"collaborators":["McGill University Health Centre/Research Institute of the McGill University Health Centre"],"completion_date":{"date":"2026-08-30","type":"ESTIMATED"},"conditions":["Oropharynx Cancer","Tonsil Cancer","Throat Cancer","Base of the Tongue Carcinoma"],"enrollment":{"count":60,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Docetaxel","otherNames":["Cisplatin, Transoral robotic surgery"],"type":"DRUG"}],"last_update":"2023-10-23","lead_sponsor":"Nader Sadeghi","official_title":"Phase II Study: Induction Chemotherapy Followed by Transoral Robotic Surgery and Neck Dissection for Definitive Management of Oropharyngeal Squamous Cell Carcinoma. (NECTORS Trial)","overall_status":"UNKNOWN","phases":["PHASE2"],"primary_completion_date":{"date":"2024-08-30","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Primary outcome: progression free survival.","timeFrame":"2 years"}],"references":[{"citation":"Sadeghi N, Mascarella MA, Khalife S, Ramanakumar AV, Richardson K, Joshi AS, Taheri R, Fuson A, Bouganim N, Siegel R. Neoadjuvant chemotherapy followed by surgery for HPV-associated locoregionally advanced oropharynx cancer. Head Neck. 2020 Aug;42(8):2145-2154. doi: 10.1002/hed.26147. Epub 2020 Mar 25.","pmid":"32212296","type":"BACKGROUND"},{"citation":"Sadeghi N, Khalife S, Mascarella MA, Ramanakumar AV, Richardson K, Joshi AS, Bouganim N, Taheri R, Fuson A, Siegel R. Pathologic response to neoadjuvant chemotherapy in HPV-associated oropharynx cancer. Head Neck. 2020 Mar;42(3):417-425. doi: 10.1002/hed.26022. Epub 2019 Nov 27.","pmid":"31773857","type":"BACKGROUND"},{"citation":"Sadeghi N, Li NW, Taheri MR, Easley S, Siegel RS. Neoadjuvant chemotherapy and transoral surgery as a definitive treatment for oropharyngeal cancer: A feasible novel approach. Head Neck. 2016 Dec;38(12):1837-1846. doi: 10.1002/hed.24526. Epub 2016 Jun 14.","pmid":"27299983","type":"BACKGROUND"},{"citation":"Sadeghi N, Subramaniam T, Richardson K, Mascarella M, Zeitouni A, Shenouda G, Sultanem K, Mlynarek A, Caglar D, Esfahani K, Joshi A, Siegel R, Goodman J, Thakkar P, Lee E, Golabi N, Ramanakumar AV, Hier M, Bouganim N. Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Human Papillomavirus-Related Oropharyngeal Cancer. JAMA Otolaryngol Head Neck Surg. 2025 Feb 1;151(2):128-134. doi: 10.1001/jamaoto.2024.3303.","pmid":"39636629","type":"DERIVED"}],"start_date":{"date":"2018-08-14","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer.","url":"https://clinicaltrials.gov/study/NCT04277858"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nectors-nct04277858"}