{"commentary":{"count":14,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":11,"youtube":3},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02539537\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"NEOPAN","nct_id":"NCT02539537","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=neopan-nct02539537. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1250,"size":"standard","size_rule":"Standard: 13–40 commentary sources"},"registry":{"acronym":"NEOPAN","arms":[{"description":"Gemcitabine 1000 mg/m² IV infusion over 30 minutes on D1 of each week for the 4 weeks of the first cycle (1 cycle = 4 weeks). For the following five cycles, gemcitabine infusion on D1, D8, and D15 of each cycle, followed by 1 week without injection (i.e. in total 4 cycles over 24 weeks; with 19 administrations of Gemcitabine).","label":"Arm A: Gemcitabine","type":"ACTIVE_COMPARATOR"},{"description":"Administered once every 14 days for 24 weeks (12 cycles). A cycle equals 14 days with injection on D1 of each cycle. Treatment starts with oxaliplatin (85 mg/m²) administration; IV infusion over 2 hours, followed by the simultaneous administration (using a Y-tubing) of folinic acid 400 mg/m² (racemic) (or 200 mg/m² if L-folinic acid) IV infusion over 2 hours and irinotecan 180 mg/m² IV infusion over 90 minutes. The irinotecan will begin 30 minutes after the start of the folinic acid infusion.\n\n5-Fluoro-uracil (5-FU) IV 2,400 mg/m²/h will be administered over 46 hours after the end of the folinic acid infusion, i.e. 1200 mg/m²/day for the duration of 2 days.\n\nTreatment will be continued for 24 weeks (12 cycles).","label":"Arm B: Folfirinox","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2023-09-25","type":"ACTUAL"},"conditions":["Pancreatic Cancer","Carcinoma"],"enrollment":{"count":171,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Gemcitabine","type":"DRUG"},{"name":"Folinic Acid","type":"DRUG"},{"name":"5-Fluoro-uracil","type":"DRUG"},{"name":"Oxaliplatin","type":"DRUG"},{"name":"Irinotecan","type":"DRUG"},{"name":"L-folinic","type":"DRUG"}],"last_update":"2024-01-09","lead_sponsor":"UNICANCER","official_title":"A Randomized Phase III Trial Comparing Chemotherapy With Folfirinox to Gemcitabine in Locally Advanced Pancreatic Carcinoma","overall_status":"COMPLETED","phases":["PHASE3"],"primary_completion_date":{"date":"2022-02","type":"ACTUAL"},"primary_outcomes":[{"measure":"Progression-Free-Survival (PFS)","timeFrame":"From randomization until disease progression or date of death, assessed up until to 128 weeks"}],"references":[{"citation":"Ducreux M, Desgrippes R, Rinaldi Y, Di Fiore F, Guimbaud R, Evesque L, Bachet JB, Vanelslander P, Lecomte T, Capitain O, Parzy A, Bolliet M, Etienne PL, Forestier J, El Hajbi F, Bignon AL, Lebrun-Ly V, De Sousa Carvalho N, Texier M, Bouche O. PRODIGE 29-UCGI 26 (NEOPAN): A Phase III Randomized Trial Comparing Chemotherapy With FOLFIRINOX or Gemcitabine in Locally Advanced Pancreatic Carcinoma. J Clin Oncol. 2025 Jul 10;43(20):2255-2264. doi: 10.1200/JCO-24-02210. Epub 2025 May 16.","pmid":"40378359","type":"DERIVED"}],"start_date":{"date":"2015-10-23","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Randomized Phase III Trial Comparing Folfirinox to Gemcitabine in Locally Advanced Pancreatic Carcinoma","url":"https://clinicaltrials.gov/study/NCT02539537"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/neopan-nct02539537"}