# NEXUS-01 (NCT06465069)

> A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

No report yet. It can be ordered.

- Drugs tested: LY4052031; LY4052031 plus pembrolizumab
- Indication: advanced or metastatic urothelial carcinoma or solid tumors

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT06465069
- Phase: PHASE1
- Status: RECRUITING
- Sponsor: Eli Lilly and Company
- Conditions: Metastatic Solid Tumor; Recurrent Solid Tumor; Advanced Solid Tumor; Urinary Bladder Neoplasm; Triple Negative Breast Cancer; Non-small Cell Lung Cancer; Esophageal Cancer; Pancreatic Cancer; Ovarian Cancer; Cervical Cancer; Head and Neck Squamous Cell Carcinoma; Prostate Cancer; Renal Pelvis Cancer; Bladder Cancer
- Interventions: LY4052031; Pembrolizumab
- Enrollment: 460
- Primary outcome: Phase 1a: To determine the recommended phase 2 dose (RP2D) optimal dose(s) of LY4052031
- Primary outcome: Phase 1b: To assess the antitumor activity of LY4052031 as monotherapy or in combination with pembrolizumab: Overall response rate (ORR)

## Questions raised in the commentary

_Automated from the 33 newest of 34 indexed sources (Nov 2025 – Sep 2026). Each question is raised in at least two. Not an Erudio report: no source links. Not medical advice._

- Whether Nectin-4 remains a viable target after EV exposure
- Whether changing payloads can overcome resistance, including after prior Topo-I ADC exposure
- How Nectin-4 ADCs should be sequenced after EV or another ADC
- How CYP2D6 status should guide dosing and toxicity management

Also discussed: adc development landscape.

## Indexed commentary on NEXUS-01 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- X threads: 31
- YouTube: 2
- Podcasts: 1

## Order

Deep, $1,950, price fixed at order: https://www.erudio.com/contact?report=nexus-01-nct06465069

## Free preview

POST https://www.erudio.com/api/trial-requests with {"nct_id": "NCT06465069", "email": "<work email>"}; the inbox owner confirms by the emailed link.