{"preliminary_commentary":{"by_channel":{"x_thread":16,"podcast":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT03904043\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"name":"NOM-ERA","nct_id":"NCT03904043","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=nom-era-nct03904043. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1250,"size":"standard","size_rule":"Standard: 151–300 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"NOM-ERA","arms":[{"description":"* Pelvic radiotherapy 5GY x 5 fractions once daily\n* Radiation to extra-mesorectal node 7 Gy x 5 fractions once daily\n* FOLFOX should begin 2-4 weeks after completion of radiotherapy and will consist of FOLFOX x 8 cycles (16 weeks).\n\n  * Oxaliplatin day 1 every 14 days\n  * Leucovorin day 1 every 14 days. Levoleucovorin may be substituted if leucovorin is not available.\n  * 5-FU bolus day 1 every 14 days\n  * 5-FU infusion day 1 every 14 days over 46 hours\n* An optional simultaneous integrated boost of 30 Gy in 5 fractions to the primary tumor is permitted","label":"Radiation + FOLFOX","type":"EXPERIMENTAL"},{"description":"* Pelvic radiotherapy 5GY x 5 fractions once daily\n* Radiation to extra-mesorectal node 7 Gy x 5 fractions once daily\n* CAPOX should begin 2-4 weeks after completion of radiotherapy and will consist of CAPOX x 5 cycles (15 weeks).\n\n  * Capecitabine 1000 mg/m\\^2 by mouth twice per day on days 1-14 of every 21 day cycle\n  * Oxaliplatin 130 mg/m\\^2 intravenous on day 1 of each 21 day cycle\n* An optional simultaneous integrated boost of 30 Gy in 5 fractions to the primary tumor is permitted","label":"Radiation + CAPOX","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2026-01-25","type":"ACTUAL"},"conditions":["Adenocarcinoma of the Lower Rectum"],"enrollment":{"count":63,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"Radiation therapy","otherNames":[],"type":"RADIATION"},{"name":"FOLFOX regimen","otherNames":[],"type":"DRUG"},{"name":"CAPOX regimen","otherNames":[],"type":"DRUG"}],"last_update":"2026-05-01","lead_sponsor":"Washington University School of Medicine","official_title":"Non-Operative Management and Early Response Assessment in Rectal Cancer","overall_status":"COMPLETED","phases":["NA"],"primary_completion_date":{"date":"2024-08-21","type":"ACTUAL"},"primary_outcomes":[{"measure":"Clinical Complete Response Rate","timeFrame":"Completion of treatment (estimated to be 22 weeks)"}],"references":[],"start_date":{"date":"2020-07-01","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Non-Operative Management and Early Response Assessment in Rectal Cancer","url":"https://clinicaltrials.gov/study/NCT03904043"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/nom-era-nct03904043"}