{"preliminary_commentary":{"by_channel":{"x_thread":3},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":null,"indication":"stage IV non-small cell lung cancer","name":"ORION","nct_id":"NCT03775486","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=orion-nct03775486. The price is an estimate of verified statements from the commentary indexed so far. Final coverage is set when the report is built. You never pay more than quoted: if the report is delivered at a smaller size, you pay that size's price, and anything paid above it is refunded. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_rule":"Never more than quoted: the buyer pays the smaller of price_usd and the price the delivered edition is sold at.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"ORION","arms":[{"description":"Durvalumab/Olaparib Combination Therapy:\n\nDurvalumab/SoC chemotherapy (initial therapy phase) followed by Durvalumab/Olaparib (maintenance phase)","label":"Durvalumab/Olaparib Combination Therapy","type":"EXPERIMENTAL"},{"description":"Durvalumab Monotherapy: Durvalumab/SoC chemotherapy (initial therapy phase) followed by Durvalumab/placebo (maintenance phase)","label":"Durvalumab Monotherapy","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2026-09-27","type":"ESTIMATED"},"conditions":["Non-small Cell Lung Cancer NSCLC"],"enrollment":{"count":401,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"Durvalumab","otherNames":["MEDI4736 (Durvalumab)"],"type":"DRUG"},{"name":"Placebo for Olaparib","otherNames":["Placebo"],"type":"DRUG"},{"name":"Olaparib","otherNames":["AZD2281 (Olaparib)"],"type":"DRUG"},{"name":"Nab-paclitaxel+carboplatin","otherNames":[],"type":"DRUG"},{"name":"Gemcitabine+carboplatin","otherNames":[],"type":"DRUG"},{"name":"Pemetrexed+carboplatin","otherNames":[],"type":"DRUG"},{"name":"Gemcitabine+cisplatin","otherNames":[],"type":"DRUG"},{"name":"Pemetrexed+cisplatin","otherNames":[],"type":"DRUG"}],"last_update":"2026-09-11","lead_sponsor":"AstraZeneca","official_title":"A Phase II Randomized, Multi-Center, Double-Blind, Global Study to Determine the Efficacy and Safety of Durvalumab Plus Olaparib Combination Therapy Compared With Durvalumab Monotherapy as Maintenance Therapy in Patients Whose Disease Has Not Progressed Following Standard of Care Platinum-Based Chemotherapy With Durvalumab in First Line Stage IV Non Small Cell Lung Cancer (ORION)","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2"],"primary_completion_date":{"date":"2021-01-11","type":"ACTUAL"},"primary_outcomes":[{"measure":"Progression-free Survival","timeFrame":"From randomization until date of objective radiological disease progression or death, or last evaluable assessment in the absence of progression, up to 18 months"}],"references":[{"citation":"Ahn MJ, Bondarenko I, Kalinka E, Cho BC, Sugawara S, Galffy G, Shim BY, Kislov N, Nagarkar R, Demedts I, Gans SJM, Mendoza Oliva D, Stewart R, Lai Z, Mann H, Shi X, Hussein M. Durvalumab in Combination With Olaparib Versus Durvalumab Alone as Maintenance Therapy in Metastatic NSCLC: The Phase 2 ORION Study. J Thorac Oncol. 2023 Nov;18(11):1594-1606. doi: 10.1016/j.jtho.2023.06.013. Epub 2023 Jun 29.","pmid":"37390980","type":"DERIVED"}],"start_date":{"date":"2018-12-21","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Study of Durvalumab+Olaparib or Durvalumab After Treatment With Durvalumab and Chemotherapy in Patients With Lung Cancer (ORION)","url":"https://clinicaltrials.gov/study/NCT03775486"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.2","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/orion-nct03775486"}