{"preliminary_commentary":{"by_channel":{"bluesky_thread":4,"x_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":false},"name":"PICS","nct_id":"NCT06108596","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=pics-nct06108596. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"PICS","arms":[{"description":"Sintilimab with Interleukin-2+CAPOX","label":"Experimental group","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2024-12-31","type":"ACTUAL"},"conditions":["Locally Advanced Rectal Adenocarcinoma"],"enrollment":{"count":33,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Sintilimab with Interleukin-2+CAPOX","otherNames":[],"type":"DRUG"}],"last_update":"2025-01-21","lead_sponsor":"The First Affiliated Hospital with Nanjing Medical University","official_title":"Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Mid-low Locally Advanced Rectal Cancer","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2024-12-31","type":"ACTUAL"},"primary_outcomes":[{"measure":"pCR","timeFrame":"From the start of initial medication to the final determination via pathology results after surgical treatment, the assessment period will be up to a maximum of 6 months."}],"references":[{"citation":"Tang J, Wang L, Yang S, Peng W, Zhang Y, Zhang Y, Jin K, Wang X, Feng Y, Sun Y. Total neoadjuvant chemotherapy combined with PD-1 blockade and IL-2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study. Signal Transduct Target Ther. 2026 May 4;11(1):163. doi: 10.1038/s41392-026-02683-8.","pmid":"42071008","type":"DERIVED"}],"start_date":{"date":"2023-10-21","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Mid-low Locally Advanced Rectal Cancer - a Single-center, Single-arm, Open-label Clinical Trail","url":"https://clinicaltrials.gov/study/NCT06108596"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/pics-nct06108596"}