{"preliminary_commentary":{"by_channel":{"x_thread":21,"youtube":1,"podcast":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02867865\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"name":"POLCAGB","nct_id":"NCT02867865","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=polcagb-nct02867865. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"POLCAGB","arms":[{"description":"Post staging laparoscopy, all patients will receive chemotherapy using Injection Gemcitabine 1000 mg/m2 delivered day 1 and 8 every 3 weeks.\n\nIn addition, Injection Cisplatin 25 mg/m2 for and 4 cycles week 1 to week 11.","label":"Chemotherapy arm","type":"ACTIVE_COMPARATOR"},{"description":"Post staging laparoscopy in Experimental arm The radiation dose will be 50-55 Gy/ 25 fractions to the gross disease and 45 Gy/ 25 fractions to suspected microscopic disease along with weekly gemcitabine (300 mg/ m2). Radiotherapy will be for 5 weeks which will be followed by 2 cycles of chemotherapy with Injection Gemcitabine (Gemcite,Gemzar) 1000 mg/m2 delivered day 1 and 8 every 3 weeks and cisplatin (Cisplat, Cytoplatin) 25 mg/m2from week 7 to week 11.\n\nDuring week 12-13 patients will undergo repeat PETCECT scan. If the scan shows partial or good response then patients will be evaluated for surgery. Surgery if possible will be done between weeks 13-15. In case of inoperable disease patients will receive further chemotherapy","label":"Chemoradiation arm","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2027-09-10","type":"ESTIMATED"},"conditions":["Gall Bladder Cancers"],"enrollment":{"count":124,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Gemcitabine","otherNames":["Gemcite","Gemzar"],"type":"DRUG"},{"name":"Cisplatin","otherNames":["Cytoplat"],"type":"DRUG"},{"name":"Chemoradiation","otherNames":["Intensity modulated radiotherapy"],"type":"RADIATION"},{"name":"PETCECT","otherNames":["PET scan"],"type":"PROCEDURE"},{"name":"Laparoscopy","otherNames":["Diagnostic laparoscopy"],"type":"PROCEDURE"}],"last_update":"2025-03-13","lead_sponsor":"Tata Memorial Hospital","official_title":"Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2","PHASE3"],"primary_completion_date":{"date":"2025-09-10","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Overall Survival","timeFrame":"6 years"}],"references":[{"citation":"Engineer R, Patkar S, Lewis SC, Sharma AD, Shetty N, Ostwal V, Ramaswamy A, Chopra S, Agrawal A, Patil P, Mehta S, Goel M. A phase III randomised clinical trial of perioperative therapy (neoadjuvant chemotherapy versus chemoradiotherapy) in locally advanced gallbladder cancers (POLCAGB): study protocol. BMJ Open. 2019 Jun 27;9(6):e028147. doi: 10.1136/bmjopen-2018-028147.","pmid":"31253621","type":"DERIVED"}],"start_date":{"date":"2016-09-06","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Perioperative Therapy Preoperative Chemotherapy Versus Chemoradiotherapy in Locally Advanced Gall Bladder Cancers","url":"https://clinicaltrials.gov/study/NCT02867865"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/polcagb-nct02867865"}