{"preliminary_commentary":{"by_channel":{"x_thread":34,"podcast":7,"youtube":4},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT04790253\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":{"generated_at":"2026-11-02T01:02:06.778Z","note":"Automated from the 38 newest of 45 indexed sources (Jul 2022 – Oct 2026). Each question is raised in at least two. Not an Erudio report: no source links. Not medical advice.","passages_read":38,"text":"- Whether PCI remains beneficial in the immunotherapy era\n- Whether MRI surveillance alone can replace PCI\n- How PCI and MRI surveillance compare on survival, cognition, and quality of life\n\nAlso discussed: trial recruitment."},"drugs_tested":[],"indication":"small-cell lung cancer","name":"PRIMALung","nct_id":"NCT04790253","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=primalung-nct04790253. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"PRIMALung","arms":[{"description":"Prophylactic cranial irradiation will be delivered at the dose of 25 Gy in 10 fractions to the whole brain.\n\nPatients must have a brain MRI performed within 28 days before randomisation and at 3, 6, 9, 12, 18 and 24 months.\n\nExtracranial imaging is recommended and will be performed per institutional standards at the discretion of the treating physician.","label":"PCI followed by brain MR surveillance","type":"ACTIVE_COMPARATOR"},{"description":"Patients must have a brain MRI performed within 28 days before randomisation and at 3, 6, 9, 12, 18 and 24 month. Clinical evaluation will be performed every 3 months.","label":"MRI Active Surveillance","type":"NO_INTERVENTION"}],"collaborators":["UNICANCER"],"completion_date":{"date":"2028-04","type":"ESTIMATED"},"conditions":["Limited Stage Small Cell Lung Cancer","Extensive-stage Small-cell Lung Cancer"],"enrollment":{"count":600,"type":"ESTIMATED"},"has_results":false,"interventions":[{"name":"Prophylactic cranial irradiation","otherNames":[],"type":"RADIATION"}],"last_update":"2026-10-16","lead_sponsor":"European Organisation for Research and Treatment of Cancer - EORTC","official_title":"PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)","overall_status":"RECRUITING","phases":["NA"],"primary_completion_date":{"date":"2028-04","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Overall survival","timeFrame":"12 Months"}],"references":[],"start_date":{"date":"2022-10-27","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)","url":"https://clinicaltrials.gov/study/NCT04790253"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/primalung-nct04790253"}