{"preliminary_commentary":{"by_channel":{"x_thread":4},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":[["avutometinib (VS-6766)","defactinib"],["avutometinib (VS-6766)"]],"indication":"recurrent KRAS-mutant or BRAF-mutant non-small cell lung cancer","name":"RAMP202","nct_id":"NCT04620330","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=ramp202-nct04620330. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":"RAMP202","arms":[{"description":"in patients with NSCLC KRAS-G12V tumor","label":"Arm 1: avutometinib (VS-6766) monotherapy","type":"EXPERIMENTAL"},{"description":"in patients with a NSCLC KRAS-G12V tumor","label":"Arm 2: avutometinib (VS-6766) in combination with defactinib","type":"EXPERIMENTAL"},{"description":"in patients with a NSCLC KRAS-other (non-G12V) tumor","label":"Arm 3: avutometinib (VS-6766) in combination with defactinib","type":"EXPERIMENTAL"},{"description":"in patients with a NSCLC BRAF-V600E tumor","label":"Arm 4: avutometinib (VS-6766) in combination with defactinib","type":"EXPERIMENTAL"},{"description":"in patients with a NSCLC BRAF-non-V600E tumor","label":"Arm 5:avutometinib (VS-6766) in combination with defactinib","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2023-12-12","type":"ACTUAL"},"conditions":["Non Small Cell Lung Cancer","KRAS Activating Mutation"],"enrollment":{"count":90,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"avutometinib (VS-6766)","otherNames":[],"type":"DRUG"},{"name":"avutometinib (VS-6766) and Defactinib","otherNames":["avutometinib (VS-6766) and VS-6063"],"type":"DRUG"}],"last_update":"2024-01-12","lead_sponsor":"Verastem, Inc.","official_title":"A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) as a Single Agent and In Combination With Defactinib (FAK Inhibitor) in Recurrent KRAS-Mutant (KRAS-MT) and BRAF-Mutant (BRAF-MT) Non-Small Cell Lung Cancer (NSCLC) (RAMP 202)","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2023-08-29","type":"ACTUAL"},"primary_outcomes":[{"measure":"To determine the optimal regimen, either avutometinib (VS-6766) monotherapy or avutometinib (VS-6766) in combination with defactinib, in KRAS-G12V NSCLC","timeFrame":"From start of treatment to confirmation of response; 24 weeks"},{"measure":"To evaluate the initial efficacy of avutometinib (VS-6766) in combination with defactinib in BRAF-MT NSCLC","timeFrame":"From start of treatment to confirmation of response; 24 weeks"},{"measure":"To determine efficacy in KRAS-other (non-G12V) NSCLC","timeFrame":"From start of treatment to confirmation of response; 24 weeks"},{"measure":"To determine the efficacy of avutometinib (VS-6766) in combination with defactinib in BRAF-MT NSCLC","timeFrame":"From start of treatment to confirmation of response; 24 weeks"}],"references":[{"citation":"Capelletto E, Bironzo P, Denis L, Koustenis A, Bungaro M, Novello S. Single agent VS-6766 or VS-6766 plus defactinib in KRAS-mutant non-small-cell lung cancer: the RAMP-202 phase II trial. Future Oncol. 2022 May;18(16):1907-1915. doi: 10.2217/fon-2021-1582. Epub 2022 Mar 14.","pmid":"35285277","type":"DERIVED"}],"start_date":{"date":"2020-12-31","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer","url":"https://clinicaltrials.gov/study/NCT04620330"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/ramp202-nct04620330"}