{"preliminary_commentary":{"by_channel":{"x_thread":3},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":false},"commentary_summary":null,"drugs_tested":null,"indication":null,"name":"RETAIN","nct_id":"NCT02710734","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=retain-nct02710734. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":750,"size":"focused","size_rule":"Focused: 1–150 verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Trimodality of Maximal TURBT#1 Followed by AMVAC and TURBT#2 and then chemoradiation followed by TURBT#3","label":"CRT","type":"EXPERIMENTAL"},{"description":"Trimodality of Maximal TURBT#1 Followed by AMVAC and TURBT#2 and then active surveillance","label":"Surveillance","type":"EXPERIMENTAL"},{"description":"Trimodality of Maximal TURBT#1 Followed by AMVAC and TURBT#2 and then intravesicle therapy followed by TURBT#3","label":"Intravesicle therapy","type":"EXPERIMENTAL"},{"description":"Trimodality of Maximal TURBT#1 Followed by AMVAC and TURBT#2 and then cystectomy","label":"Radical Cystectomy","type":"EXPERIMENTAL"}],"collaborators":[],"completion_date":{"date":"2025-12","type":"ACTUAL"},"conditions":["Urothelial Carcinoma of the Bladder"],"enrollment":{"count":78,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Methotrexate","otherNames":[],"type":"DRUG"},{"name":"Vinblastine","otherNames":[],"type":"DRUG"},{"name":"Doxorubicin","otherNames":[],"type":"DRUG"},{"name":"Cisplatin","otherNames":[],"type":"DRUG"},{"name":"Intensity modulated radiation therapy (IMRT)","otherNames":[],"type":"RADIATION"},{"name":"Transurethral Resection of Bladder tumor","otherNames":[],"type":"PROCEDURE"},{"name":"5-FU","otherNames":[],"type":"DRUG"},{"name":"Mitomycin C","otherNames":[],"type":"DRUG"}],"last_update":"2026-05-22","lead_sponsor":"Fox Chase Cancer Center","official_title":"A Phase II Trial of Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN BLADDER)","overall_status":"COMPLETED","phases":["PHASE2"],"primary_completion_date":{"date":"2025-11-27","type":"ACTUAL"},"primary_outcomes":[{"measure":"Metastasis-free survival (MFS) at 2 years.","timeFrame":"24 months"}],"references":[{"citation":"Geynisman DM, Abbosh PH, Ross E, Zibelman MR, Ghatalia P, Anari F, Mark JR, Stamatakis L, Hoffman-Censits JH, Viterbo R, Greenberg RE, Churilla TM, Horwitz EM, Hallman MA, Smaldone MC, Uzzo R, Chen DYT, Kutikov A, Plimack ER. Phase II Trial of Risk-Enabled Therapy After Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer (RETAIN 1). J Clin Oncol. 2025 Mar 20;43(9):1113-1122. doi: 10.1200/JCO-24-01214. Epub 2024 Dec 16.","pmid":"39680823","type":"DERIVED"},{"citation":"Jiang DM, Chung P, Kulkarni GS, James ND, Sridhar SS. Lack of Evidence Does Not Equal Lack of Benefit: Neoadjuvant Chemotherapy and Trimodality Therapy in Selected Patients with Muscle-Invasive Bladder Cancer : In response to: Dirk Bohmer and Arne Grun. Lacking Evidence to Recommend Neoadjuvant Chemotherapy and Definitive Radiotherapy in Muscle-Invasive Bladder Cancer. Curr Oncol Rep. 2021 Mar 3;23(3):36. doi: 10.1007/s11912-021-01035-9. No abstract available.","pmid":"33660142","type":"DERIVED"}],"start_date":{"date":"2016-02-24","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN)","url":"https://clinicaltrials.gov/study/NCT02710734"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/retain-nct02710734"}