{"preliminary_commentary":{"by_channel":{"x_thread":89,"youtube":22,"podcast":21,"x_video":4,"bluesky_thread":1},"note":"Preliminary. Indexed podcasts, YouTube videos and X posts that name this trial so far. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT05099172\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's free public preview; the full report is still bought."},"commentary_summary":null,"drugs_tested":[["sevabertinib (BAY 2927088)"]],"indication":"advanced EGFR- and/or HER2-mutant non-small cell lung cancer","name":"SOHO-01","nct_id":"NCT05099172","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=soho-01-nct05099172. The price is an estimate of verified statements from the commentary indexed so far, fixed at order. Final coverage is set when the report is built. We build the report within 24 hours of confirming the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 301+ verified statements, estimated at 14 per indexed commentary source"},"registry":{"acronym":null,"arms":[{"description":"Doses of BAY2927088 will be increased in a stepwise fashion up to the MTD or MAD.","label":"Dose escalation","type":"EXPERIMENTAL"},{"description":"Dose Escalation and Backfill run concurrently","label":"Backfill","type":"EXPERIMENTAL"},{"description":"Eight independent groups (group A, B1, B2, C, D, E, F, G, H, I, J) are planned. 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Sevabertinib in Advanced HER2-Mutant Non-Small-Cell Lung Cancer. N Engl J Med. 2025 Nov 6;393(18):1819-1832. doi: 10.1056/NEJMoa2511065. Epub 2025 Oct 17.","pmid":"41104928","type":"DERIVED"}],"start_date":{"date":"2021-10-25","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)","url":"https://clinicaltrials.gov/study/NCT05099172"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"3.1","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/soho-01-nct05099172"}