# SWOG-S1826 (NCT03907488)

> Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

No report yet. It can be ordered.

## Registry

- Registry record: https://clinicaltrials.gov/study/NCT03907488
- Phase: PHASE3
- Status: ACTIVE_NOT_RECRUITING
- Sponsor: National Cancer Institute (NCI)
- Conditions: Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma; Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma; Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma; Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma; Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma; Classic Hodgkin Lymphoma; Lymphocyte-Rich Classic Hodgkin Lymphoma
- Interventions: Biospecimen Collection; Brentuximab Vedotin; Computed Tomography; Dacarbazine; Doxorubicin Hydrochloride; Filgrastim; Magnetic Resonance Imaging; Nivolumab; Pegfilgrastim; Positron Emission Tomography; Quality-of-Life Assessment; Questionnaire Administration; Radiation Therapy; Vinblastine Sulfate
- Enrollment: 994
- Primary outcome: Progression Free Survival (PFS)

## Questions raised in the commentary

_Automated from the 40 newest of 340 indexed sources (Jan 2026 – Oct 2026). Each question is raised in at least two. Not an Erudio report: no source links. Not medical advice._

- How to choose between N-AVD and BrECADD for individual patients
- How end-of-treatment PET positivity should guide radiotherapy decisions
- Whether real-world outcomes and tolerability support N-AVD use in older adults

Also discussed: EBV status and histology, ctDNA response assessment.

## Indexed commentary on SWOG-S1826 so far

Podcasts, YouTube videos and X posts we have indexed that name the trial. This is where a report starts, not where it ends: the build searches for more, so finished reports usually cover more than this.

- X threads: 224
- YouTube: 62
- Podcasts: 41
- Bluesky threads: 9
- X videos: 4

## Order

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## Free preview

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