{"commentary":{"count":93,"free_build_floor":8,"listing_floor":3,"by_channel":{"x_thread":59,"podcast":19,"youtube":15},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT01924819\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"TOPGEAR","nct_id":"NCT01924819","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=topgear-nct01924819. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 41+ commentary sources"},"registry":{"acronym":"TOPGEAR","arms":[{"description":"2 cycles preoperative chemotherapy with: epirubicin + cisplatin + 5-fluorouracil. (5-fluorouracil may be replaced with capecitabine).\n\nOR epirubicin + oxaliplatin + capecitabine OR 3 cycles of 5-fluorouracil +Leucovorin + oxaliplatin + docetaxel\n\n5 weeks preoperative chemoradiotherapy.\n\nGastric resection.\n\n3 cycles adjuvant chemotherapy with: epirubicin + cisplatin + 5-fluorouracil. (5-fluorouracil may be replaced with capecitabine).\n\nOR epirubicin + oxaliplatin + capecitabine OR 4 cycles of 5-fluorouracil +Leucovorin + oxaliplatin + docetaxel","label":"Preoperative chemoradiotherapy","type":"EXPERIMENTAL"},{"description":"3 cycles preoperative chemotherapy with: epirubicin + cisplatin + 5-fluorouracil. (5-fluorouracil may be replaced with capecitabine).\n\nOR epirubicin + oxaliplatin + capecitabine OR 4 cycles of 5-fluorouracil +Leucovorin + oxaliplatin + docetaxel\n\nGastric resection.\n\n3 cycles adjuvant chemotherapy with: epirubicin + cisplatin + 5-fluorouracil. (5-fluorouracil may be replaced with capecitabine) OR epirubicin + oxaliplatin + capecitabine OR 4 cycles of 5-fluorouracil +Leucovorin + oxaliplatin + docetaxel","label":"Preoperative chemotherapy","type":"ACTIVE_COMPARATOR"}],"collaborators":["National Health and Medical Research Council, Australia","Trans Tasman Radiation Oncology Group","European Organisation for Research and Treatment of Cancer - EORTC","NCIC Clinical Trials Group"],"completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"conditions":["Gastric Cancer"],"enrollment":{"count":574,"type":"ACTUAL"},"has_results":false,"interventions":[{"name":"Epirubicin + cisplatin + 5-fluorouracil OR epirubicin + cisplatin + capecitabine OR epirubicin + oxaliplatin + capecitabine OR 5-Fluorouracil + leucovorin + oxaliplatin + docetaxel","type":"DRUG"},{"name":"Preoperative chemoradiotherapy","type":"RADIATION"},{"name":"Gastric resection","type":"PROCEDURE"}],"last_update":"2025-03-04","lead_sponsor":"Australasian Gastro-Intestinal Trials Group","official_title":"A Randomised Phase II/III Trial of Preoperative Chemoradiotherapy Versus Preoperative Chemotherapy for Resectable Gastric Cancer","overall_status":"ACTIVE_NOT_RECRUITING","phases":["PHASE2","PHASE3"],"primary_completion_date":{"date":"2026-12-31","type":"ESTIMATED"},"primary_outcomes":[{"measure":"Overall survival","timeFrame":"Up to 5 years"}],"references":[{"citation":"Leong T, Smithers BM, Michael M, Haustermans K, Wong R, Gebski V, O'Connell RL, Zalcberg J, Boussioutas A, Findlay M, Willis D, Moore A, Murray WK, Lordick F, O'Callaghan C, Swallow C, Darling G, Miller D, Strickland A, Liberman M, Mineur L, Simes J; Australasian Gastro-Intestinal Trials Group, National Health and Medical Research Council Clinical Trials Centre, Trans-Tasman Radiation Oncology Group, European Organisation for Research and Treatment of Cancer, and Canadian Cancer Trials Group. Preoperative Chemoradiotherapy for Resectable Gastric Cancer. N Engl J Med. 2024 Nov 14;391(19):1810-1821. doi: 10.1056/NEJMoa2405195. Epub 2024 Sep 14.","pmid":"39282905","type":"DERIVED"}],"start_date":{"date":"2009-09"},"study_type":"INTERVENTIONAL","title":"Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma","url":"https://clinicaltrials.gov/study/NCT01924819"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/topgear-nct01924819"}