{"commentary":{"count":114,"free_build_floor":8,"listing_floor":3,"by_channel":{"podcast":51,"x_thread":49,"youtube":14},"note":"Indexed podcasts, YouTube videos and X posts that name this trial. A report screens them, searches for more and cites what clinicians said when it is built."},"free_build":{"available":true,"how":"POST https://www.erudio.com/api/trial-requests with {\"nct_id\": \"NCT02975934\", \"email\": \"<work email>\"}. The person who owns that inbox must confirm by the emailed link; agents cannot confirm. The result is the report's public preview; the full report is still bought."},"name":"TRITON3","nct_id":"NCT02975934","offer":{"currency":"USD","how":"Order at https://www.erudio.com/contact?report=triton3-nct02975934. The price is fixed at order. We build the report after the order and deliver it when it passes our checks; if it cannot be built to our standard, nothing is charged.","price_usd":1950,"size":"deep","size_rule":"Deep: 41+ commentary sources"},"registry":{"acronym":"TRITON3","arms":[{"description":"Oral rucaparib (monotherapy).","label":"Rucaparib","type":"EXPERIMENTAL"},{"description":"Oral abiraterone acetate (monotherapy, given in combination with prednisone). Oral enzalutamide (monotherapy). Intravenous docetaxel (monotherapy, given in combination with prednisone or prednisolone).","label":"Abiraterone acetate or Enzalutamide or Docetaxel","type":"ACTIVE_COMPARATOR"}],"collaborators":["Foundation Medicine"],"completion_date":{"date":"2024-08-08","type":"ACTUAL"},"conditions":["Metastatic Castration Resistant Prostate Cancer"],"enrollment":{"count":405,"type":"ACTUAL"},"has_results":true,"interventions":[{"name":"Rucaparib","type":"DRUG"},{"name":"Abiraterone acetate or Enzalutamide or Docetaxel","type":"DRUG"}],"last_update":"2025-07-25","lead_sponsor":"pharmaand GmbH","official_title":"TRITON3: A Multicenter, Randomized, Open Label Phase 3 Study of Rucaparib Versus Physician's Choice of Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Associated With Homologous Recombination Deficiency","overall_status":"COMPLETED","phases":["PHASE3"],"primary_completion_date":{"date":"2022-08-25","type":"ACTUAL"},"primary_outcomes":[{"measure":"Radiographic Progression-free Survival (rPFS) by IRR in Participants With a BRCA Alteration","timeFrame":"From enrollment to primary completion of study (Total follow-up was up to approximately 4 years)"},{"measure":"Radiographic Progression-free Survival (rPFS) by IRR in Participants With a BRCA or ATM Alteration Combined","timeFrame":"From enrollment to primary completion of study (Total follow-up was up to approximately 4 years)"}],"references":[{"citation":"Fizazi K, Piulats JM, Reaume MN, Ostler P, McDermott R, Gingerich JR, Pintus E, Sridhar SS, Bambury RM, Emmenegger U, Lindberg H, Morris D, Nole F, Staffurth J, Redfern C, Saez MI, Abida W, Daugaard G, Heidenreich A, Krieger L, Sautois B, Loehr A, Despain D, Heyes CA, Watkins SP, Chowdhury S, Ryan CJ, Bryce AH; TRITON3 Investigators. Rucaparib or Physician's Choice in Metastatic Prostate Cancer. N Engl J Med. 2023 Feb 23;388(8):719-732. doi: 10.1056/NEJMoa2214676. Epub 2023 Feb 16.","pmid":"36795891","type":"RESULT"},{"citation":"Collins K, Cheng L. Reprint of: morphologic spectrum of treatment-related changes in prostate tissue and prostate cancer: an updated review. Hum Pathol. 2023 Mar;133:92-101. doi: 10.1016/j.humpath.2023.02.007. Epub 2023 Mar 8.","pmid":"36898948","type":"DERIVED"},{"citation":"Maia MC, Salgia M, Pal SK. Harnessing cell-free DNA: plasma circulating tumour DNA for liquid biopsy in genitourinary cancers. Nat Rev Urol. 2020 May;17(5):271-291. doi: 10.1038/s41585-020-0297-9. Epub 2020 Mar 17.","pmid":"32203306","type":"DERIVED"}],"start_date":{"date":"2017-06-13","type":"ACTUAL"},"study_type":"INTERVENTIONAL","title":"A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency","url":"https://clinicaltrials.gov/study/NCT02975934"},"report":null,"schema_id":"erudio.trial_listing","schema_version":"2.0","state":"listed","state_text":"No report yet. It can be ordered.","url":"https://www.erudio.com/trials/triton3-nct02975934"}