HO95

Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.

Official title

A Randomized Phase III Study to Compare Bortezomib, Melphalan, Prednisone (VMP) With High Dose Melphalan Followed by Bortezomib, Lenalidomide, Dexamethasone (VRD) Consolidation and Lenalidomide Maintenance in Patients With Newly Diagnosed Multiple Myeloma

Phase

Phase 3

Status

Completed

Conditions

Multiple Myeloma

Interventions

Bortezomib, Melphalan, Prednisone (VMP); 1 or 2 cycle(s) HDM (High Dose Melphalan); 2 cycles of Bortezomib, Lenalidomide, Dexamethasone (VRD)

Arms

• R1: 4 cycles Bortezomib, Melphalan, Prednisone (VMP) · Active comparator
• R1: 1 (2) cycle(s) HDM · Experimental
• R2: none · No intervention
• R2: 2 cycles of VRD · Experimental

Enrollment

1,503

Primary outcomes

• For all registered patients: progression free survival (PFS) as defined by time from registration to progression or death from any cause (whichever occurs first).
• For all patients included in R1; PFS as defined by time from randomization R1 to progression or death from any cause whichever comes first
• For all patients included in R2; PFS as defined by time from randomization R2 to progression or death from any cause whichever comes first

Sponsor

Stichting Hemato-Oncologie voor Volwassenen Nederland with European Myeloma Network B.V., Gruppo Italiano Malattie EMatologiche dell'Adulto, DSMM (Deutsche Studiengruppe Multiples Myelom), NMSG (Nordic Myeloma Study Group), Central European Myeloma Study Group

Start

Jan 2011

Primary completion

Dec 2020

Results posted

No

Registry record

NCT01208766 · updated Jan 6, 2026

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