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Clinical trial · no report yet · Phase 3

IMbrave 251

A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads18
Podcasts10
YouTube9

The trial

ClinicalTrials.gov
Official title
A Phase III, Open-Label, Randomized Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumab
Phase
Phase 3
Status
Active, not recruiting
Conditions
Unresectable Hepatocellular Carcinoma
Interventions
Atezolizumab; Lenvatinib; Sorafenib
Arms
  • Atezolizumab + Lenvatinib or Sorafenib · Experimental
  • Lenvatinib or Sorafenib · Active comparator
Enrollment
557
Primary outcomes
  • Overall Survival (OS)
Sponsor
Hoffmann-La Roche
Start
Apr 26, 2021
Primary completion
Oct 14, 2026 (estimated)
Results posted
No
Registry record
NCT04770896 · updated Aug 25, 2026