Clinical trial · no report yet · Phase 3
NCT01726452
NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)
- NCT01726452 ↗
- Completed
- Cancer Trials Ireland
- 83 commentary sources found
- Deep
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Commentary we found
Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.
| Channel | Found | |
|---|---|---|
| X threads | 65 | |
| Podcasts | 12 | |
| YouTube | 6 |
The trial
ClinicalTrials.gov- Official title
- Neo-AEGIS (NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study): Randomised Clinical Trial of Neoadjuvant and Adjuvant Chemotherapy (Modified MAGIC or FLOT Regimen) vs. Neoadjuvant Chemoradiation (CROSS Protocol) in Adenocarcinoma of the Oesophagus and Oesophago-gastric Junction
- Phase
- Phase 3
- Status
- Completed
- Conditions
- Adenocarcinoma of the Oesophagus; Adenocarcinoma of the Oesophago-gastric Junction; Oesophageal Tumours; Junctional Tumours; Oesophageal Cancer
- Interventions
- Epirubicin; Cisplatin / Oxaliplatin; 5 Flourouracil/ Capecitabine; (41.4 Gy/23 fractions); Paclitaxel; Carboplatin; Docetaxel; Oxaliplatin; Leucovorin; 5-Fluorouracil
- Arms
- A (Modified MAGIC) OR Arm A: FLOT · Experimental
- B (CROSS) · Experimental
- Enrollment
- 377
- Primary outcomes
- Overall survival
- Sponsor
- Cancer Trials Ireland with Southampton Clinical Trials Unit, Copenhagen University Hospital, Rigshospitalet, Centre Hospitalier Régional, Universitaire de Lille
- Start
- Jan 24, 2013
- Primary completion
- Aug 4, 2022
- Results posted
- No
- Registry record
- NCT01726452 · updated Sep 30, 2022
Publications
linked from the registry- Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group. Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial. Lancet Gastroenterol Hepatol. 2023 Nov;8(11):1015-1027. doi: 10.1016/S2468-1253(23)00243-1. Epub 2023 Sep 18. PubMed 37734399
- Reynolds JV, Preston SR, O'Neill B, Baeksgaard L, Griffin SM, Mariette C, Cuffe S, Cunningham M, Crosby T, Parker I, Hofland K, Hanna G, Svendsen LB, Donohoe CL, Muldoon C, O'Toole D, Johnson C, Ravi N, Jones G, Corkhill AK, Illsley M, Mellor J, Lee K, Dib M, Marchesin V, Cunnane M, Scott K, Lawner P, Warren S, O'Reilly S, O'Dowd G, Leonard G, Hennessy B, Dermott RM. ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS). BMC Cancer. 2017 Jun 3;17(1):401. doi: 10.1186/s12885-017-3386-2. PubMed 28578652