Clinical trial · no report yet · Phase 1
NCT04526691
Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)
- NCT04526691 ↗
- Active not recruiting
- Daiichi Sankyo
- 64 commentary sources found
- Deep
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Commentary we found
Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.
| Channel | Found | |
|---|---|---|
| X threads | 35 | |
| Podcasts | 19 | |
| YouTube | 10 |
The trial
ClinicalTrials.gov- Official title
- Phase 1b, Multicenter, Open-label Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Pembrolizumab With or Without Platinum Chemotherapy in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (TROPION-Lung02)
- Phase
- Phase 1
- Status
- Active not recruiting
- Conditions
- Advanced or Metastatic NSCLC
- Interventions
- Datopotamab deruxtecan; KEYTRUDA®; Carboplatin; Cisplatin
- Arms
- Datopotamab deruxtecan (Dato-DXd) · Experimental
- Enrollment
- 145
- Primary outcomes
- Number of Participants with Dose-limiting Toxicities (DLTs) and Treatment-emergent Adverse Events (TEAEs)
- Sponsor
- Daiichi Sankyo with Merck Sharp & Dohme LLC
- Start
- Sep 15, 2020
- Primary completion
- Apr 14, 2024
- Results posted
- No
- Registry record
- NCT04526691 · updated May 15, 2026
Publications
linked from the registry- Levy B, Paz-Ares L, Lin CC, Herbert S, Yang TY, Tolcher A, Lou Y, Zenke Y, Cortinovis D, Felip E, Domine M, Leventakos K, Calvo E, Horiike A, Pan E, Basak P, Lin D, Gu W, Chiaverelli R, Chisamore MJ, Goto Y. Datopotamab Deruxtecan Plus Pembrolizumab With or Without Platinum-Based Chemotherapy for Advanced or Metastatic NSCLC: The Phase Ib TROPION-Lung02 Trial. J Thorac Oncol. 2026 Jul;21(7):103688. doi: 10.1016/j.jtho.2026.103688. Epub 2026 Mar 21. PubMed 41871716