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Clinical trial · no report yet · Phase 3

NCT06564324

A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Preliminary discovery

Commentary in our index that names this trial so far

Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.

ChannelFound
X threads6

The trial

ClinicalTrials.gov
Official title
A Phase 3 Multicenter Open-label Study of Taletrectinib Versus a Standard of Care ROS1-Tyrosine Kinase Inhibitor (Crizotinib) in TKI-Naïve Patients With ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer (TRUST-III)
Phase
Phase 3
Status
Recruiting
Conditions
Non Small Cell Lung Cancer
Interventions
Taletrectinib; Crizotinib
Arms
  • Taletrectinib · Experimental
  • Crizotinib · Active comparator
Enrollment
194 (estimated)
Primary outcomes
  • PFS (Assessed by BIRC)
Sponsor
Nuvation Bio Inc.
Start
Nov 27, 2024
Primary completion
Jan 2029 (estimated)
Results posted
No
Registry record
NCT06564324 · updated Apr 13, 2026