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Clinical trial · no report yet · Phase 3

OlympiAD

Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.

We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.

Commentary we found

Podcasts, YouTube videos and X posts in our index that name this trial. A report screens them, searches for more and cites what clinicians said when it is built.

ChannelFound
YouTube35
Podcasts24
X threads6

The trial

ClinicalTrials.gov
Official title
A Phase III, Open Label, Randomised, Controlled, Multi-centre Study to Assess the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations.
Phase
Phase 3
Status
Completed
Conditions
Breast Cancer Metastatic; BRCA 1 Gene Mutation; BRCA 2 Gene Mutation
Interventions
Olaparib; Physician's choice chemotherapy
Arms
  • Olaparib · Experimental
  • Physician's choice chemotherapy · Active comparator
Enrollment
302
Primary outcomes
  • Progression-free Survival (PFS) Using Blinded Independent Central Review (BICR) According to Modified Response Evaluation Criteria In Solid Tumours (RECIST v1.1)
Sponsor
AstraZeneca with Myriad Genetic Laboratories, Inc., Merck Sharp & Dohme LLC
Start
Mar 27, 2014
Primary completion
Dec 9, 2016
Results posted
Yes
Registry record
NCT02000622 · updated Feb 13, 2026

Publications

linked from the registry
  • Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P. Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation. N Engl J Med. 2017 Aug 10;377(6):523-533. doi: 10.1056/NEJMoa1706450. Epub 2017 Jun 4. PubMed 28578601