Clinical trial · no report yet · Phase 2
STUDY00016033
mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma
- NCT04251715 ↗
- Terminated
- OHSU Knight Cancer Institute
- Focused
We haven't built a report for this trial yet. This page shows the registry record and the public commentary we found that names the trial. A report reads that commentary and sets out what clinicians said about the trial, each point linked to its source. How reports are made.
Preliminary discovery
Commentary in our index that names this trial so far
Podcasts, YouTube videos and X posts we have indexed. A report screens them, searches for more and cites what clinicians said when it is built, so final coverage is set at build.
| Channel | Found | |
|---|---|---|
| X threads | 4 |
The trial
ClinicalTrials.gov- Official title
- A Phase II Study of Induction Systemic mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone Given Concurrently With Systemic mFOLFIRI as a First-Line Therapy in Patients With Unresectable Liver-Dominant Intrahepatic Cholangiocarcinoma
- Phase
- Phase 2
- Status
- Terminated
- Conditions
- Liver and Intrahepatic Bile Duct Carcinoma; Stage III Intrahepatic Cholangiocarcinoma AJCC v8; Stage IIIA Intrahepatic Cholangiocarcinoma AJCC v8; Stage IIIB Intrahepatic Cholangiocarcinoma AJCC v8; Stage IV Intrahepatic Cholangiocarcinoma AJCC v8; Unresectable Intrahepatic Cholangiocarcinoma
- Interventions
- Dexamethasone; Floxuridine; Implanted Medical Device; Irinotecan; Leucovorin; Oxaliplatin; Quality-of-Life Assessment
- Arms
- mFOLFIRINOX, Floxuridine-DEX, mFOLFIRI · Experimental
- Enrollment
- 5
- Primary outcomes
- Frequency of Abnormal Liver Function
- Disease Control Rate (DCR) - During HAI+SYS
- Sponsor
- OHSU Knight Cancer Institute with Oregon Health and Science University
- Start
- Apr 28, 2021
- Primary completion
- Mar 20, 2024
- Results posted
- Yes
- Registry record
- NCT04251715 · updated Jun 25, 2026
Publications
linked from the registry- Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004 Aug;240(2):205-13. doi: 10.1097/01.sla.0000133083.54934.ae. PubMed 15273542
- Blair AB, Alobuia WM, Palta M, Raman SS, Levine MH, Benson AB 3rd, D'Angelica MI, Cloyd JM. Locoregional Treatment Options for Locally Advanced Intrahepatic Cholangiocarcinoma. J Natl Compr Canc Netw. 2025 Aug 14;23(9):e257085. doi: 10.6004/jnccn.2025.7085. PubMed 40812353