DAWN-303

An aspect marked incomplete is a question the public commentary did not let us answer. We show it rather than hide it.

Screened window

Jan 9, 2026 → Oct 26, 2026

Cited window

Jan 9, 2026 → Oct 26, 2026

Retrieved

Oct 28, 2026

Title

A Randomized, Double-Blind, Phase 3 Study of Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma (DAWN-303)

Registry

NCT07522073

Study IDs

INCB161734-303

Sponsor

Incyte Corporation

Collaborators

Qiagen Manchester Ltd

Design

Phase 3 · Interventional, randomized, parallel

Status

Recruiting

Enrollment

588 estimated

Start

2026-04-09 actual

Primary completion

2028-09-15 estimated

Primary endpoint

Overall Survival (OS)

Interventions

3 registered

This report does not judge efficacy, estimate HCP prevalence or consensus or give treatment advice.

• –Discussion that does not name the trial may be missing from this edition.
• –Not yet captured in this edition: a view on response durability with targeted therapy plus chemotherapy in pancreatic cancer.
• –Some passages in the sources used in this report were not fully assessed for clinician views, so a view there may be missing from this edition.
• –85 statements in the sources reviewed for this edition are about other patients or topics, or only mention the trial, and are not counted.
• –Further source limits: discussion that describes the trial without naming it may be incomplete; some discussion that describes the trial without naming it may be missing; sources about other trials are not included.
• –This report represents the sources reviewed for this edition, not all HCPs or public discussion. Unnamed references and variant trial or drug spellings may be missed.
• –Some earlier-phase discussions, several organization-authored trial announcements and part of the PeerView presentation were not fully assessed for their relevance to the frontline decision. Absence from this report is not evidence that no additional views exist.
• –No exact-trial results publication or full protocol is included. Product-label documentation for the interventions is also absent; the report supports no conclusion about approval status.
• –Early monotherapy, previously treated and combination findings must not be treated as outcomes in DAWN-303's previously untreated population.
• –Some speakers' identities or clinical roles are not established in the sources used in this report; each statement is attributed only as far as its source shows.
• –Unattributed PeerView passages may be from a named participant, but their speaker cannot be identified from the available evidence. They are not additional independent voices.
• –Repeated posts, reposts and quoted earlier posts do not establish independent assessments or consensus. Publication and post dates do not establish session dates, readout dates or changes of mind.

How reports are built and checked: Methods.

Last checked for new commentary Oct 29, 2026. A new or changed finding gets a new version number; added evidence alone is a smaller update. No corrections.

Paste this into ChatGPT, Claude, Microsoft Copilot or your own agent. It previews this report through the free Erudio MCP server, tells you whether it answers your question, and orders it if you ask. Some agents ask you to confirm pasted instructions before acting; that is expected.

Help me decide whether to buy the Erudio report "DAWN-303" (NCT07522073), and buy it for me if I ask. Erudio reports cover what clinicians say in public about one clinical trial, with every verified statement linked to its source.

1. Use the free Erudio MCP server at https://mcp.erudio.com/free; it needs no sign-in. Nothing needs installing: if it is not connected in this app and you can make HTTP requests, call it directly with JSON-RPC POSTs to that URL (initialize, then tools/call), sending "Accept: application/json, text/event-stream". Call get_report_card with slug "dawn-303-07522073". If you cannot make requests, read https://www.erudio.com/reports/dawn-303-nct07522073.md instead.
2. In a few lines, tell me what the report covers: its findings, its verified statements and sources, its evidence window, what it leaves out, and the price of each product (offer). Then ask what I need it for, and say plainly whether this report answers it.
3. If I want it, ask for my work email and the product: the current edition, or 3, 6 or 12 months of weekly updates. Call create_order with report "NCT07522073", that product and email, then show me the quote and the checkout_url to pay by card. If you have a payment client for HTTP 402 payments and I agree, you can pay the pay_url instead. Nothing is charged until one is paid.
4. Once it is paid, call get_order with the status_url: it returns my license key. Then use the Erudio MCP server at https://mcp.erudio.com/mcp with the header "Authorization: Bearer <key>". Call read_report with report_id erudio-nct07522073 and sections ["all"], and summarize the findings for me with their sources. The full report is large (about 500 KB): save the response to a file and work from it rather than printing it. If you cannot, read sections ["narratives"] first, the executive summary and analysis.

When you tell me what clinicians said, give each view as theirs, with its source. Counts are the sources the report kept, not the share of clinicians who agree. Reports are not medical advice.
Keep the key private to my organization.

curl https://www.erudio.com/reports/dawn-303-nct07522073.json
curl https://www.erudio.com/reports/dawn-303-nct07522073.md

# MCP, no sign-in (https://mcp.erudio.com/free)
get_report_card({ "slug": "dawn-303-07522073" })