ICARUS-LUNG01

An aspect marked incomplete is a question the public commentary did not let us answer. We show it rather than hide it.

Screened window

Apr 20, 2024 → Oct 4, 2026

Cited window

Apr 20, 2024 → Oct 4, 2026

Retrieved

Oct 31, 2026

Title

Phase 2, Open Label Study of DS-1062a, an Anti-TROP-2-Antibody-Drug Conjugate (ADC), in Patients With Advanced and/or Unresectable Non-Small Cell Lung Cancer (NSCLC), With Biomarker Analysis to Characterize Response to Therapy

Registry

NCT04940325

Study IDs

2023-505924-71-00 · 2020/3187 (CSET Number (Gustave Roussy ID))

Sponsor

Gustave Roussy, Cancer Campus, Grand Paris

Collaborators

Daiichi Sankyo

Design

Phase 2 · Interventional, single group

Status

Active, not recruiting

Enrollment

100 actual

Registered

2021-06-25

Start

2021-05-12 actual

Primary completion

2028-04 estimated

Primary endpoint

Evaluation of objective response rate (ORR) based on investigator assessment

Interventions

1 registered

This report does not judge efficacy, estimate HCP prevalence or consensus or give treatment advice.

• –Discussion that does not name the trial may be missing from this edition.
• –Not yet captured in this edition: a view on antibody–drug conjugate efficacy and safety in heavily pretreated non-small cell lung cancer.
• –Some passages in the sources used in this report were not fully assessed for clinician views, so a view there may be missing from this edition.
• –37 statements in the sources reviewed for this edition are about other patients or topics, or only mention the trial, and are not counted.
• –Further source limits: discussion that describes the trial without naming it may be incomplete; some discussion that describes the trial without naming it may be missing; sources about other trials are not included.
• –The sources reviewed are selected public discussions, not a representative sample of HCP opinion. Source totals and repost activity cannot be interpreted as numbers of independent clinicians or the prevalence of a view.
• –Relevant commentary may be missing when it does not use the trial identifier or familiar study-name variants. Some potentially relevant passages were not fully evaluated, and additional presentation summaries are not represented.
• –Some authors remain unnamed, and several video remarks cannot be assigned to a named participant. They cannot establish additional independent endorsements or disagreements.
• –Some speakers' identities or clinical roles are not established in the sources used in this report; each statement is attributed only as far as its source shows.
• –Descriptions of presenting or involvement in ICARUS-LUNG01 are attributed source descriptions, not independently confirmed trial roles. Such appraisals should not be counted as external validation.
• –Full protocol and exact-trial publication text were not available. Linked article descriptions provide qualitative context rather than a full evaluation of methods, results or mechanistic analyses.
• –No exact DS-1062a regulatory label was available. Predictions and criticism about approval do not establish an agency decision or current regulatory status.
• –Reported response proportions differ between sources, and one presentation relay does not identify its PFS comparator. These differences cannot be resolved from the sources reviewed.
• –Organizational commentary and linked article descriptions are identified separately from HCP views; favorable organizational wording does not increase the certainty of efficacy, safety or biomarker conclusions.

How reports are built and checked: Methods.

Last checked for new commentary Oct 31, 2026. A new or changed finding gets a new version number; added evidence alone is a smaller update. No corrections.

Paste this into ChatGPT, Claude, Microsoft Copilot or your own agent. It previews this report through the free Erudio MCP server, tells you whether it answers your question, and orders it if you ask. Some agents ask you to confirm pasted instructions before acting; that is expected.

Help me decide whether to buy the Erudio report "ICARUS-LUNG01" (NCT04940325), and buy it for me if I ask. Erudio reports cover what clinicians say in public about one clinical trial, with every verified statement linked to its source.

1. Use the free Erudio MCP server at https://mcp.erudio.com/free; it needs no sign-in. Nothing needs installing: if it is not connected in this app and you can make HTTP requests, call it directly with JSON-RPC POSTs to that URL (initialize, then tools/call), sending "Accept: application/json, text/event-stream". Call get_report_card with slug "icarus-lung01-04940325". If you cannot make requests, read https://www.erudio.com/reports/icarus-lung01-nct04940325.md instead.
2. In a few lines, tell me what the report covers: its findings, its verified statements and sources, its evidence window, what it leaves out, and the price of each product (offer). Then ask what I need it for, and say plainly whether this report answers it.
3. If I want it, ask for my work email and the product: the current edition, or 3, 6 or 12 months of weekly updates. Call create_order with report "NCT04940325", that product and email, then show me the quote and the checkout_url to pay by card. If you have a payment client for HTTP 402 payments and I agree, you can pay the pay_url instead. Nothing is charged until one is paid.
4. Once it is paid, call get_order with the status_url: it returns my license key. Then use the Erudio MCP server at https://mcp.erudio.com/mcp with the header "Authorization: Bearer <key>". Call read_report with report_id erudio-nct04940325 and sections ["all"], and summarize the findings for me with their sources. The full report is large (about 500 KB): save the response to a file and work from it rather than printing it. If you cannot, read sections ["narratives"] first, the executive summary and analysis.

When you tell me what clinicians said, give each view as theirs, with its source. Counts are the sources the report kept, not the share of clinicians who agree. Reports are not medical advice.
Keep the key private to my organization.

curl https://www.erudio.com/reports/icarus-lung01-nct04940325.json
curl https://www.erudio.com/reports/icarus-lung01-nct04940325.md

# MCP, no sign-in (https://mcp.erudio.com/free)
get_report_card({ "slug": "icarus-lung01-04940325" })