KEYNOTE-975

An aspect marked incomplete is a question the public commentary did not let us answer. We show it rather than hide it.

Screened window

Mar 31, 2021 → Oct 16, 2026

Cited window

Jun 22, 2022 → Oct 16, 2026

Retrieved

Oct 18, 2026

Title

A Randomized, Double-blind, Placebo-controlled Phase 3 Trial of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Receiving Concurrent Definitive Chemoradiotherapy (KEYNOTE 975)

Registry

NCT04210115

Study IDs

3475-975 · MK-3475-975 (MSD) · KEYNOTE-975 (MSD) · PHRR200210-002490 (PHRR) · 205261 (Japic-CTI) · 2022-501531-16-00 (EU CT) · U1111-1281-0822 (UTN) · 2019-002006-51

Sponsor

Merck Sharp & Dohme LLC

Design

Phase 3 · Interventional, randomized, parallel

Status

Completed

Enrollment

703 actual

Start

2020-02-28 actual

Primary completion

2026-01-21 actual

Primary endpoint

Event-free Survival (EFS)

Interventions

8 registered

This report does not judge efficacy, estimate HCP prevalence or consensus or give treatment advice.

• –Discussion that does not name the trial may be missing from this edition.
• –For 1 recording, a transcript separated by speaker was not available, so quotes come from the original automatic transcript and may lack speaker labels.
• –Some passages in the sources used in this report were not fully assessed for clinician views, so a view there may be missing from this edition.
• –79 statements in the sources reviewed for this edition discuss other treatment settings or topics unrelated to this trial's question and are not included.
• –Further source limits apply, so some matching discussion may be missing.
• –The sources reviewed are not a representative sample of HCP opinion, and multiple formats of one discussion do not represent independent agreement.
• –Some potentially relevant posts and a video were unavailable to read. Parts of several long discussions were not completely assessed, so additional relevant opinions may be missing.
• –Several treatment, histology and safety comments cannot be reliably assigned to a named speaker. A program roster, institutional reference or professional identifier does not resolve that uncertainty.
• –Some speakers' identities or clinical roles are not established in the sources used in this report; each statement is attributed only as far as its source shows.
• –The negative EFS statements relay sponsor announcements. No KEYNOTE-975 results publication, quantitative efficacy analysis, detailed subgroup analysis or comparative safety analysis is among the sources reviewed.
• –Earlier anticipatory comments and later announcement reactions come from different dates and contexts. Their sequence does not establish a change of mind or direct disagreement over detailed results.
• –Some transcript wording is unclear, including an overexpression qualifier in the adenocarcinoma discussion; the initial organ-preservation proposal is truncated.
• –Cross-disease analogies, other-study response figures, institutional experience and anecdotal tolerability observations are not KEYNOTE-975 outcomes.
• –No full protocol document or complete regulatory evidence is available here. Descriptions of prescribing labels and local treatment standards remain the contributors' accounts.
• –General CPS-scoring concerns do not establish inaccurate testing in KEYNOTE-975, and local historical reporting thresholds must not be substituted for trial criteria.

How reports are built and checked: Methods.

Last checked for new commentary Oct 18, 2026. A new or changed finding gets a new version number; added evidence alone is a smaller update.

Paste this into ChatGPT, Claude, Microsoft Copilot or your own agent. It previews this report through the free Erudio MCP server, tells you whether it answers your question, and orders it if you ask. Some agents ask you to confirm pasted instructions before acting; that is expected.

Help me decide whether to buy the Erudio report "KEYNOTE-975" (NCT04210115), and buy it for me if I ask. Erudio reports cover what clinicians say in public about one clinical trial, with every verified statement linked to its source.

1. Use the free Erudio MCP server at https://mcp.erudio.com/free; it needs no sign-in. Nothing needs installing: if it is not connected in this app and you can make HTTP requests, call it directly with JSON-RPC POSTs to that URL (initialize, then tools/call), sending "Accept: application/json, text/event-stream". Call get_report_card with slug "keynote-975-04210115". If you cannot make requests, read https://www.erudio.com/reports/keynote-975-nct04210115.md instead.
2. In a few lines, tell me what the report covers: its findings, its verified statements and sources, its evidence window, what it leaves out, and the price of each product (offer). Then ask what I need it for, and say plainly whether this report answers it.
3. If I want it, ask for my work email and the product: the current edition, or 3, 6 or 12 months of weekly updates. Call create_order with report "NCT04210115", that product and email, then show me the quote and the checkout_url to pay by card. If you have a payment client for HTTP 402 payments and I agree, you can pay the pay_url instead. Nothing is charged until one is paid.
4. Once it is paid, call get_order with the status_url: it returns my license key. Then use the Erudio MCP server at https://mcp.erudio.com/mcp with the header "Authorization: Bearer <key>". Call read_report with report_id erudio-nct04210115 and sections ["all"], and summarize the findings for me with their sources. The full report is large (about 500 KB): save the response to a file and work from it rather than printing it. If you cannot, read sections ["narratives"] first, the executive summary and analysis.

When you tell me what clinicians said, give each view as theirs, with its source. Counts are the sources the report kept, not the share of clinicians who agree. Reports are not medical advice.
Keep the key private to my organization.

curl https://www.erudio.com/reports/keynote-975-nct04210115.json
curl https://www.erudio.com/reports/keynote-975-nct04210115.md

# MCP, no sign-in (https://mcp.erudio.com/free)
get_report_card({ "slug": "keynote-975-04210115" })